지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
로타바이러스에 대하여 저해 효능을 갖는 probiotic Lactobacillus ruminis와 Bifidobacterium longum의 초음파 처리된 균체의 항바이러스 작용 기전을 알아보기 위해 로타바이러스 감염 시 나타나는 IL-8, MCP-1, IFN-α, 및 IFN-β의 변화를 확인하고자 하였다. 바이러스 역가 및 바이러스 감염 최적의 조건을 산정하기 위해 로타바이러스액을 cytopathic effect 확인 및 plaque assay를 수행하였다. LR0211과 BL1206의 투여군이 로타바이러스 감염된 초기에는 대조군에 비교하여 chemokine의 분비량 변화가 미미하였으나, 감염이 진행되고 24시간 후 감염 부위가 넓어짐에 따라 IL-8와 MCP-1의 발현을 유도하여 활성화된 면역 세포를 감염된 부위로 유도하여 감염 부위의 면역 기능을 증가시키는 것을 확인하였다. 또한, 인터페론의 발현을 유도하는 1형 매개 반응으로서 IFN-α 및 IFN-β를 각각 증가시키는 기전으로 항바이러스 효과를 나타냄을 확인하였다.
목차
Materials and Methods
Results
Discussion
적요
References
참고문헌 (15)
참고문헌 신청
Angel J, Franco MA, and Greenberg HB. 2012. Rotavirus immune response and correlates of protection. Curr. Opin. Virol. 2, 419? 425.
Chen SC, Tan LB, Huang LM, and Chen KT. 2012. Rotavirus infection and the current status of rotavirus vaccines. J. Formos. Med. Assoc. 111, 183?193.
Fernandez-Duarte KP, Olaya-Galan NN, Salas-Cardenas SP, Lopez-Rozo J, and Gutierrez-Fernandez MF. 2018. Bifidobacterium adolescentis (DSM 20083) and Lactobacillus casei (Lafti L26-DSL): Probiotics able to block the in vitro adherence of rotavirus in MA104 cells. Probiotics Antimicrob. Proteins 10, 56?63.
Hernandez PP, Mahlakoiv T, Yang I, Schwierzeck V, Nguyen N, Guendel F, Gronke K, Ryffel B, Hoelscher C, Dumoutier L, et al. 2015. Interferon-λ and interleukin-22 cooperate for the induction of interferon-stimulated genes and control of rotavirus infection. Nat. Immunol. 16, 698?707.
Holloway G and Coulson BS. 2013. Innate cellular responses to rotavirus infection. J. Gen. Virol. 94, 1151?1160.
Chen SC, Tan LB, Huang LM, and Chen KT. 2012. Rotavirus infection and the current status of rotavirus vaccines. J. Formos. Med. Assoc. 111, 183?193.
Fernandez-Duarte KP, Olaya-Galan NN, Salas-Cardenas SP, Lopez-Rozo J, and Gutierrez-Fernandez MF. 2018. Bifidobacterium adolescentis (DSM 20083) and Lactobacillus casei (Lafti L26-DSL): Probiotics able to block the in vitro adherence of rotavirus in MA104 cells. Probiotics Antimicrob. Proteins 10, 56?63.
Hernandez PP, Mahlakoiv T, Yang I, Schwierzeck V, Nguyen N, Guendel F, Gronke K, Ryffel B, Hoelscher C, Dumoutier L, et al. 2015. Interferon-λ and interleukin-22 cooperate for the induction of interferon-stimulated genes and control of rotavirus infection. Nat. Immunol. 16, 698?707.
Holloway G and Coulson BS. 2013. Innate cellular responses to rotavirus infection. J. Gen. Virol. 94, 1151?1160.
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UCI(KEPA) : I410-ECN-0101-2021-475-001424934