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학술저널
저자정보
Mun, Jung-Hyun (Department of Oriental Pharmaceutical Science, Kyung Hee East-West Pharmaceutical Research Institute) Lee, Sang-Gon (Department of Oriental Pharmaceutical Science, Kyung Hee East-West Pharmaceutical Research Institute) Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Science, Kyung Hee University) Jung, Ji-Wook (Department of Herbal Medicinal Resource, College of Health and Welfare) Yoon, Byung-Hoon (Department of Life and Nanopharmaceutical Science, Kyung Hee University) Shin, Bum-Young (Department of Pharmaceutical Science, Kyung Hee East-West Pharmaceutical Research Institute) Kim, Sun-Ho (Department of Life and Nanopharmaceutical Science, Kyung Hee University) Ryu, Jong-Hoon (Department of Oriental Pharmaceutical Science, Department of Life and Nanopharmaceutical Science, Kyung Hee University, Kyung Hee East-West Pharmaceutical Research Institute, College of)
저널정보
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제15권 제2호
발행연도
2007.1
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83 - 88 (6page)

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The roots of Liriope platyphylla (Liliaceae) are widely used in traditional Chinese medicine. In the present study, we investigated the effects of ethanol (70%) extract of the roots of Liriope platyphylla (ELP70) on learning and memory using behavioral and immunohistochemical methods in mice. Control animals were treated with vehicle (10% Tween 80). With sub-chronic treatments of ELP70 (p.o.) for 14 days, the latency time was significantly increased compared with that of the vehicle-treated control group (50, 100 and 200 mg/kg; P<0.05). Moreover, immunopositive cells for brain derived neurotrophic factor (BDNF) were significantly increased in the hippocapmpal dentate gyrus and CA1 regions after ELP70 treatments for 14 days (50, 100 and 200 mg/kg; P < 0.05). In addition, those cells for nerve growth factor (NGF) were also increased in the hippocapmpal dentate gyrus region (50, 100 and 200 mg/kg; P<0.05). These results suggest that the sub-chronic administration of ELP70 improves learning and memory, and that their beneficial effects are mediated, in part, by the enhancement of BDNF or NGF expression.

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