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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 212 - 220 (9page)
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Red Liriope platyphylla (RLP) has been manufactured from Liriope platyphylla (L. platyphylla, LP) roots using steaming process and investigated as a curative agent for treatment of diabetes, obesity and neurodegenerative disorders. To examine the precautionary effects of aqueous extract RLP (AEtRLP) on the preclinical stages of Alzheimer’s Disease (AD), alterations of the key factors influencing AD were investigated in Tg2576 mice after AEtRLP7 treatment for 4 months. Aβ-42 peptides level was significantly decreased in the brain of AEtRLP7-treated Tg2576 mice compared to vehicle-treated Tg2576 mice, although significant differences on improving behavioral defects were not observed in the same group. The concentration of nerve growth factor (NGF) in serum was also higher in AEtRLP7-treated Tg2576 mice than vehicle-treated Tg2576 mice. However, the phosphorylation of TrkA and Erk among the downstream effectors of the high affinity NGF receptor was significantly lower in AEtRLP7-treated Tg2576 mice. A similar pattern was observed in the expression level of downstream effectors within low affinity NGF receptor. Overall, these results suggest that AEtRLP7 can contribute to preventing the production and deposition of Aβ-42 peptides during the early progression stage of AD in the brain of Tg2576 mice through increased NGF secretion.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Kim K / 2008 / Korean red ginseng stimulates insulin release from isolated rat pancreatic islets / J Ethnopharmacol 120 (2) : 190 ~ 195
2. [학술지(정기간행물)] - 최선일 / 2011 / Effects of Steaming Time and Frequency for Manufactured Red Liriope platyphylla on the Insulin Secretion Ability and Insulin Receptor Signaling Pathway / Laboratory Animal Research 27 (2) : 117 ~ 126
3. [학술지(정기간행물)] - Lee HR / 2012 / Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats / Int J Mol Med 30 (4) : 905 ~ 913
4. [학술지(정기간행물)] - 이혜련 / 2013 / Red Liriope platyphylla stimulated the insulin secretion through the regulation of calcium concentration in / Laboratory Animal Research 29 (2) : 84 ~ 95
5. [학술지(정기간행물)] - Choi SI / 2012 / Differential effects of the steaming time and frequency for manufactured red Liriope platyphylla on nerve growth factor secretion ability, nerve growth factor receptor signaling pathway and regulation of calcium concentration / Mol Med Rep 6 (5) : 1160 ~ 1170
2. [학술지(정기간행물)] - 최선일 / 2011 / Effects of Steaming Time and Frequency for Manufactured Red Liriope platyphylla on the Insulin Secretion Ability and Insulin Receptor Signaling Pathway / Laboratory Animal Research 27 (2) : 117 ~ 126
3. [학술지(정기간행물)] - Lee HR / 2012 / Red Liriope platyphylla contains a large amount of polyphenolic compounds which stimulate insulin secretion and suppress fatty liver formation through the regulation of fatty acid oxidation in OLETF rats / Int J Mol Med 30 (4) : 905 ~ 913
4. [학술지(정기간행물)] - 이혜련 / 2013 / Red Liriope platyphylla stimulated the insulin secretion through the regulation of calcium concentration in / Laboratory Animal Research 29 (2) : 84 ~ 95
5. [학술지(정기간행물)] - Choi SI / 2012 / Differential effects of the steaming time and frequency for manufactured red Liriope platyphylla on nerve growth factor secretion ability, nerve growth factor receptor signaling pathway and regulation of calcium concentration / Mol Med Rep 6 (5) : 1160 ~ 1170
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