메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Bae, Jun-Tae (R & D Center, Hanbul Cosmetics Co.) Sim, Gwan-Sub (R & D Center, Hanbul Cosmetics Co.) Kim, Jin-Hwa (R & D Center, Hanbul Cosmetics Co.) Pyo, Hyeong-Bae (R & D Center, Hanbul Cosmetics Co.) Yun, Jong-Won (Department of Biotechnology, Daegu University) Lee, Bum-Chun (R & D Center, Hanbul Cosmetics Co.)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제9호
발행연도
2007.1
수록면
1,116 - 1,123 (8page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Superoxide radical scavenging activity and DPPH radical scavenging activity were assessed in order to evaluate the antioxidant effect of the Sorbus commixta Hedl. extract (SCoE). SCoE was also treated with several carbohydrate-hydrolytic enzymes that significantly increased the total phenol and flavonoid composition of SCoE. The enzymatically treated SCoE was then assessed for antioxidative activity. The most efficient radical scavenging activity was observed when SCoE was treated with -glucanase. The radical scavenging activity of ${\beta}-glucanase-treated$ SCoE (${\beta}-GSCoE$) enhanced the viability of human dermal fibroblasts (HDFs) exposed to ultraviolet (UV) light. The intracellular reactive oxygen species (ROS) scavenging activity of ${\beta}-GSCoE$ was assessed using UVB (20 $mJ/cm^2$)-irradiated HDFs. UVB irradiation increased dichlorofluorescein (DCF) fluorescence, which was measured by a 5-(6-)chloromethyl-2',7'-dichlorodihydrofluorescein diacetate ($CM-H_2DCFDA$). DCF-fluorescence was significantly decreased in the ${\beta}-GSCoE-containing$ culture medium, suggesting that ${\beta}-GSCoE$ scavenges free radicals. The protective effect was further verified by assessing the expression of matrix metalloproteinase-1 (MMP-1) in UVA-irradiated HDFs. The treatment of UVA-irradiated HDFs with ${\beta}-GSCoE$ resulted in a dose-dependent decrease in the expression level of MMP-1 protein and mRNA. These results suggest that ${\beta}-GSCoE$ may mitigate the effects of photoaging in skin by reducing UV-induced adverse skin reactions.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0