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논문 기본 정보

자료유형
학술저널
저자정보
Trung, Tran-Quoc (College of Pharmacy, Kangwon National University) Long, Pham-Hai (College of Pharmacy, Kangwon National University) Al-Abd, Ahmed M (Department of Biomedical Sciences, College of Medicine, Catholic University) Ku, Hyo-Jeong (Department of Biomedical Sciences, College of Medicine, Catholic University) Lee, Ho-Yoon (College of Pharmacy, Chungnam National University) Hwang, Sung-Joo (College of Pharmacy, Chungnam National University) Kim, Kyeong-Ho (College of Pharmacy, Kangwon National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제7호
발행연도
2007.1
수록면
890 - 897 (8page)

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A method was developed and fully validated for the determination of bevantolol, an adrenergic-receptor blocker, in human plasma. Bevantolol and betaxolol as internal standard (I.S) were extracted from 1mL of human plasma by solid phase extraction technique using Sep-pak silica cartridge. Chromatographic separation was accomplished under isocratic conditions using a reverse-phase $C_8$ analytical column and mixture of dibasic ammonium phosphate (pH 5.7; 50mM)-acetonitrile (75:25, v/v) as mobile phase, with a defection wavelength at 220 nm. The method was proved to be specific by testing six different human plasma sources. Linearity was established for the concentration ranges of 40-1600 ng/mL with correlation coefficent of 0.9995. The lower limit of quantification 40 ng/mL with precision of 10.9% as C.V%.

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