Antioxidant Flavone Glycosides from the Leaves of Sasa borealis

Park, Hae-Suk; Lim, Ju-Hee; Kim, Hyun-Jung; Choi, Hyun-Jin; Lee, Ik-Soo

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자료유형: 학술저널

저자정보: Park, Hae-Suk (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) Lim, Ju-Hee (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) Kim, Hyun-Jung (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) Choi, Hyun-Jin (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) Lee, Ik-Soo (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)

저널정보: 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제2호

발행연도: 2007.1

수록면: 161 - 166 (6page)

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Sasa borealis (Poaceae) is a perennial medicinal plant which is a major source of bamboo leaves in Korea. The n-BuOH extract of S. borealis leaves exhibited significant antioxidant activity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and a cytoprotective effect against oxidative damage in HepG2 cells. Bioactivity-guided fractionation by column chromatography led to the isolation of two antioxidative flavonoid C-glycoside derivatives, isoorientin (2) and isoorientin 2"-O-${\alpha}$-L-rhamnoside (4) along with tricin 7-O-${\beta}$-D-glucopyranoside (1) and apigenin 6-C-${\beta}$-D-xylopyranosyl-8-C-${\beta}$-D-glucopyranoside (3). Their structures were identified on the basis of chemical and spectroscopic methods. The radical scavenging activity and cytoprotective effect against oxidative damage of all the isolated compounds were also evaluated. Isoorientin (2) and isoorientin 2-O-${\alpha}$-L-rhamnoside (4) showed potent free radical scavenging activity with IC$_{50}$ values of 9.5 and 34.5 ${\mu}$M, respectively, and strong cytoprotective effects against t-BOOH-induced oxidative damage in HepG2 cells, at very low concentrations of 1.1 ${\mu}$M isoorientin and 0.8 ${\mu}$M isoorientin 2-O-${\alpha}$-L-rhamnoside. This is the first report of the isolation and antioxidant activity of compounds 2 and 4 from S. borealis.

#Sasa borealis #Bamboo leaves #Antioxidative activity #Cytoprotective effect #Isoorientin #Isoorientin-2-O-${alpha}$-L-rhamnoside

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