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논문 기본 정보

자료유형
학술저널
저자정보
Choi, Yun-Sik (Department of Pharmacology, The Catholic University) Cho, Kyung-Ok (Department of Pharmacology, The Catholic University, Cell Death Disease Research Center, College of Medicine, The Catholic University) Kim, Seong-Yun (Department of Pharmacology, The Catholic University, Cell Death Disease Research Center, College of Medicine, The Catholic University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제5호
발행연도
2007.1
수록면
641 - 645 (5page)

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Ischemic insult enhances the proliferation of precursor cells in the dentate subgranular zone. This study was performed to determine whether fluoxetine further promotes the neurogenesis induced by transient forebrain ischemia in the rat dentate gyrus. Transient forebrain ischemia was induced by four-vessel occlusion for 10 min. First, to investigate whether the short-termtreatment of fluoxetine influences ischemia-induced cell proliferation, rats were administered fluoxetine (5 mg/kg, i.p.) or a vehicle on days three to nine post-ischemia, and 5-bromo-2'-deoxyuridine-5'-monophosphate (BrdU, 75 mg/kg, i.p.) one hour after the last fluoxetine injection. On examination one day later, the number of BrdU-labeled cells was not signifcantly different between the fluoxetine- and vehicle-treated groups. Second, to Identify whether the chronic treatment of fluoxetine has an effect on the survival of ischemia-induced newborn cells, rats were administered fluoxetine or a vehicle on days 3 to 23 post-ischemia, and BrdU (75mg/kg, three times) nine days post-ischemia. On examination four weeks after the BrdU injec-tion, the number of BrdU-labeled cells was not signifcantly different between the fluoxetine-and vehicle-treated groups. Also, the rate of neuronal maturation was not signifcantly different between the two groups. These results show that fluoxetine does not affect the ischerniainduced increase of neurogenesis in the dentate gyrus of the adult rat.

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