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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제12호
- 발행연도
- 2007.1
- 수록면
- 1,584 - 1,589 (6page)
이용수
초록· 키워드
오류제보하기
Integrins consist of transmembrane glycoproteins noncovalently associated to form ${\alpha}{\beta}$ heterodimers. Various ${\alpha}{\beta}$ associations determine binding specieficities for cell surface molecules of the immunoglobulin superfamily as well as for extracellular matrix components. Through their cytoplasmic domains, integrins are responsible for the transmission of signals between the intracellular and the extracellular environment. We immobilized an integrin ${\alpha}5{\beta}1$ microarray on a ProteoChip to screen Korean medicinal plant extracts for binding activity. The microarray preserved the integrin ${\alpha}5{\beta}1-fibronectin$ interaction, and was suppressed by the synthetic RGD peptide. We identified ten extracts with high integrin affinity using a high-throughput, competitive inhibition assay. We also demonstrate the biological function of these extracts in HUVECs.
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