지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제28권 제9호
- 발행연도
- 2005.1
- 수록면
- 1,092 - 1,096 (5page)
이용수
초록· 키워드
오류제보하기
Huperzine A-loaded microspheres composed of poly(D,L-lactide-co-glycolide) were prepared by an O/w emulsion solvent evaporation method. The characterization of the microspheres such as drug loading, size, shape and release profile was described. The in vitro release in the initial 7 days was nearly linear with $10\%$ released per day. Thereafter drug release rate became slow gradually and about $90\%$ drug released at day 21. The in vitro release rate determined by dialysis bag method had a good correlation with the in vivo release rate. Huperzine A aqueous solution was intramuscularly injected (i.m.) at 0.4mg/kg and microspheres were intramuscularly injected at 8.4 mg eq huperzine A/kg in rats. The maxium plasma concentration $(C_{max})$ after i.m. microspheres was only $32\%$ of that after i.m. solution. Drug in plasma could be detectd until day 14 and about $5\%$ of administered dose was residued at the injection site at day 14. The relative bioavailability of huperzine A microspheres over a period of 14 days was $94.7\%$. Inhibition of acyecholinesterase activity (AchE) in rat's cortex, hippocampus and striatum could sustain for about 14 days. In conclusion, huperzine A-loaded microspheres possessed a prolonged and complete drug release with significant inhibition of AchE for 2 weeks in rats.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
용매증발법에 의한 부피바카인 microsphere의 제조 및 평가
약학회지
2000 .01
-
Enhanced Antigen Delivery Systems Using Biodegradable PLGA Microspheres for Single Step Immunization
대한의생명과학회지
2006 .12
-
용매증발법에 의한 부피바카인 마이크로스피어의 제조 및 평가 (II)
약학회지
2001 .01
-
Preparation and Therapeutic Evaluation of DNA-Loaded PLGA Microspheres
대한약학회 학술대회
2004 .01
-
Effects of Solvent Selection and Fabrication Method on the Characteristics of Biodegradable Poly(lactide-co-glycolide) Microspheres Containing Ovalbumin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
-
Investigation of PEG Modification Effects on Drug Release from PLGA Microspheres
대한약학회 학술대회
2001 .01
-
Preparation and Evaluation of Methacrylate copolymer Microspheres of Piroxicam
대한약학회 학술대회
2002 .01
-
Preparation and in vitro release of LHRH agonist containing Poly(d, l-lactide-co-glycolide) microspheres
대한약학회 학술대회
2001 .01
-
Preparation of biodegradable microspheres containing water-soluble drug, $\beta$-lactam$ antibiotic
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
-
FITC Albumin degradation and release from PLGA microsphere
대한약학회 학술대회
2001 .01
-
Effects of Preparation Method and Evaluations on Structural Integrity in Model Antigen-Containing Biodegradable Microspheres for Vaccine Delivery
대한의생명과학회지
2006 .09
-
Development of New Reverse Micellar Microencapsulation Technique to Load Water-Soluble Drug into PLGA Microspheres
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
Preparation of Sodium Alginate Microspheres Containing Hydrophilic $\beta-lactam$ antibiotics
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
-
Preparation and Characterization of Poly(D,L-lactide-co-glycolide) Microspheres containing PEGylated Peptide
대한약학회 학술대회
2000 .01
-
A Comparative study for single-shot immunization of diphtheria toxoid with combined PLGA microspheres.
대한약학회 학술대회
2002 .01
-
Assessment of Biodegradability of Polymeric Microspheres in vivo: Poly(DL-lactic acid), poly(L-lactic acid) and poly(DL-lactide-co-glycolid) microspheres
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1993 .01
-
Formation of peptide adduct during in vitro release of GHRP-6 containing poly(dl-lactide-co-glycolide) microspheres
대한약학회 학술대회
2001 .01
-
Drug Targeting to Lungs by Way of Microspheres
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Preparation of magnetic gelatin microspheres for the targeting of drugs
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1986 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0