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자료유형
학술저널
저자정보
Yang, Kyoung Hee (Department of Food and Biotechnology, Korea University) Yun, Bohyun (Department of Animal Science and Institute of Milk Genomics, Chonbuk National University) Choi, Hye Jin (Department of Animal Science and Institute of Milk Genomics, Chonbuk National University) Ryu, Sangdon (Department of Animal Science and Institute of Milk Genomics, Chonbuk National University) Lee, Woong Ji (Department of Animal Science and Institute of Milk Genomics, Chonbuk National University) Oh, Mi-Hwa (Animal Products Research and Development Division, National Institute of Animal Science, Rural Development Administration) Song, Min-Ho (Division of Animal and Dairy Science, Chungnam National University) Kim, Jong Nam (Department of Beef Science, Korean National College of Agriculture and Fisheries) Oh, Sangnam (Department of Functional Food and Biotechnology, Jeonju University) Kim, Younghoon (Department of Animal Science and Institute of Milk Genomics, Chonbuk National University) Kim, Young Jun (Department of Food and Biotechnology, Korea University)
저널정보
한국축산식품학회 Food science of animal resources Food science of animal resources 제39권 제1호
발행연도
2019.1
수록면
84 - 92 (9page)

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Listeria monocytogenes is a major cause of serious foodborne illness in the dairy foods. Although Caenorhabditis elegans model is well established as a virulence model of pathogenic bacteria, its application on L. monocytogenes is critically unclear. The objective of this study was to carry out an evaluation of L. monocytogenes toxicity using C. elegans nematode as a simple host model. We found that C. elegans nematodes have high susceptibility to L. monocytogenes infection, as a consequence of accumulation of bacteria in the worms' intestine. However, L. innocua, which is known to be non-toxic, is not accumulate in the intestine of worms and is not toxic similarly to Escherichia coli OP50 known as the normal feed source of C. elegans. Importantly, immune-associated genes of C. elegans were intensely upregulated more than 3.0-fold when they exposed to L. monocytogenes. In conclusion, we established that C. elegans is an effective model for studying the toxicity of L. monocytogenes and we anticipate that this system will result in the discovery of many potential anti-listeria agents for dairy foods.

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