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논문 기본 정보

자료유형
학술저널
저자정보
Ha, Ho-Kyung (Department of Animal Bioscience [Institute of Agriculture and Life Science], Gyeongsang National University) Nam, Gyeong-Won (Kawoo Commerce Co., Ltd.) Khang, Dongwoo (Department of Physiology, School of Medicine, Gachon University) Park, Sung Jean (College of Pharmacy, Gachon University) Lee, Mee-Ryung (Department of Food and Nutrition, Daegu University) Lee, Won-Jae (Department of Animal Bioscience [Institute of Agriculture and Life Science], Gyeongsang National University)
저널정보
한국축산식품학회 한국축산식품학회지 한국축산식품학회지 제37권 제1호
발행연도
2017.1
수록면
123 - 133 (11page)

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The development of a new manufacturing process, a two-step temperature treatment, to modulate the physicochemical properties of nanoparticles including the size is critical. This is because its physicochemical properties can be key factors affecting the cellular uptake and the bioavailability of bioactive compounds encapsulated in nanoparticles. The aims of this study were to produce (beta-lactoglobulin) ${\beta}-lg$ nanoparticles and to understand how two-step temperature treatment could affect the formation and physicochemical properties of ${\beta}-lg$ nanoparticles. The morphological and physicochemical properties of ${\beta}-lg$ nanoparticles were determined using atomic force microscopy and a particle size analyzer, respectively. Circular dichroism spectroscopy was used to investigate the secondary structure of ${\beta}-lg$. The surface hydrophobicity and free thiol groups of ${\beta}-lg$ were increased with a decrease in sub-ambient temperature and an increase in mild heat temperature. As sub-ambient temperature was decreased, a decrease in ${\alpha}-helical$ content and an increase in ${\beta}-sheet$ content were observed. The two-step temperature treatment firstly involved a sub-ambient temperature treatment from 5 to $20^{\circ}C$ for 30 min, followed secondly by a mild heat temperature treatment from 55 to $75^{\circ}C$ for 10 min. This resulted in the production of spherically-shaped particles with a size ranging from 61 to 214 nm. Two-way ANOVA exhibited the finding that both sub-ambient and mild heat temperature significantly (p<0.0001) affected the size of nanoparticles. Zeta-potential values of ${\beta}-lg$ nanoparticles were reduced with increasing mild heat temperature. In conclusion, two-step temperature treatment was shown to play an important role in the manufacturing process - both due to its inducement of the conformational changes of ${\beta}-lg$ during nanoparticle formation, and due to its modulation of the physicochemical properties of ${\beta}-lg$ nanoparticles.
#${beta}-lactoglobulin$ #nanoparticle #two-step temperature process #conformational change

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참고문헌 (34)

참고문헌 신청
Alizadeh-Pasdar, N. / 2000 / Comparison of protein surface hydrophobicity measured at various pH values using three different fluorescent probes / J. Agric. Food Chem 48:328~334 google schola Birnbaum, D. / 2000 / Controlled release of beta-estradiol from PLGA microparticles: The effect of organic phase solvent on encapsulation and release / J. Controlled Release 65:375~387 google schola Bruschi, M. L. / 2003 / Gelatin microparticles containing propolis obtained by spray-drying technique: Preparation and characterization / Int. J. Pharm 264:45~55 google schola Bryant, C. M. / 2000 / Influence of NaCl and CaCl2 on cold-set gelation of heat-denatured whey protein / J. Food Sci 65:801~804 google schola Chen, L. / 2006 / Food protein-based materials as nutraceutical delivery systems / Trends Food Sci. Technol 17:272~283 google schola

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