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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 72 - 79 (8page)
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초록· 키워드
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Arbutin is a hydroquinone derivative with a glucose moiety. As a tyrosinase inhibitor, it is widely used as a skin-whitening cosmetic agent for the treatment of cutaneous hyperpigmentary disorders, such as melasma and freckles. In the medical field, many studies have addressed the use of arbutin in various tumors, but the mechanism for tumor uptake of arbutin is still unclear. In this paper, we radiolabeled arbutin using radioiodine and studied its pharmacokinetics and tumor uptake via biodistribution experiments and single-photon emission computed tomography (SPECT) imaging. Radiolabeled $^{131}I-arbutin$ was stable for up to 24 h in PBS and serum. Biodistribution studies and SPECT imaging indicated high uptake of the compound in the bladder and kidneys shortly after injection. Twenty-four hours post-injection, significant deiodination was observed. Apart from high thyroid uptake, selective tumor uptake was clearly observed. The tumor-to-muscle and tumor-to-blood ratios were 26 and 9, respectively.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Kubo I / 1992 / Phenolic constituents of California buckeye fruit / Phytochemistry 31:3793~3794
Maeda K / 1996 / Arbutin: mechanism of its depigmenting action in human melanocyte culture / J Pharmacol Exp Ther 276:765~769
Sugimoto K / 2004 / Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model / Biol Pharm Bull 27:510~514
Solano F / 2006 / Hypopigmenting agents: an updated review on biological, chemical and clinical aspects / Pigment Cell Res 19:550~571
Ertam I / 2008 / Efficiency of ellagic acid and arbutin in melisma: a randomized, prospective, open-label study / J Dermatol 35:570~574
Maeda K / 1996 / Arbutin: mechanism of its depigmenting action in human melanocyte culture / J Pharmacol Exp Ther 276:765~769
Sugimoto K / 2004 / Inhibitory effects of alpha-arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model / Biol Pharm Bull 27:510~514
Solano F / 2006 / Hypopigmenting agents: an updated review on biological, chemical and clinical aspects / Pigment Cell Res 19:550~571
Ertam I / 2008 / Efficiency of ellagic acid and arbutin in melisma: a randomized, prospective, open-label study / J Dermatol 35:570~574
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