Serum Levels of Interleukin-8 and Tumor Necrosis Factor-alpha in Coal Workers' Pneumoconiosis: One-year Follow-up Study

Lee, Jong-Seong; Shin, Jae-Hoon; Lee, Joung-Oh; Lee, Kyung-Myung; Kim, Ji-Hong; Choi, Byung-Soon

추천

검색

자료유형: 학술저널

저자정보: Lee, Jong-Seong (Occupational Lung Diseases Institute, COMWEL) Shin, Jae-Hoon (Occupational Lung Diseases Institute, COMWEL) Lee, Joung-Oh (Occupational Lung Diseases Institute, COMWEL) Lee, Kyung-Myung (Occupational Lung Diseases Institute, COMWEL) Kim, Ji-Hong (Ansan WCI Hospital, COMWEL) Choi, Byung-Soon (Occupational Lung Diseases Institute, COMWEL)

저널정보: 산업안전보건연구원 Safety and health at work : SH@W Safety and health at work : SH@W 제1권 제1호

발행연도: 2010.1

수록면: 69 - 79 (11page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objectives: Various cytokines induced by inhalation of coal dust may mediate inflammation and lead to tissue damage or fibrosis, such as coal workers' pneumoconiosis (CWP). Methods: To investigate the relevance of serum cytokines in CWP, the levels of serum interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-${\alpha}$) as CWP biomarkers in 110 retired coal miners (22 controls and 88 CWP subjects) were related to cross sectional findings and 1-year progressive changes of the pneumoconiosis. Progressive changes of CWP were evaluated by paired comparison of chest radiographs. Analysis by a receiver operating characteristic curve assessed the biomarker potential of each cytokine. Results: The mean serum IL-8 level was significantly higher in CWP compared to controls and IL-8 levels correlated with the degree of CWP. The median serum TNF-${\alpha}$ level was significantly higher in subjects with progressive CWP compared to subjects without CWP progression. The area under the ROC curve for IL-8 (0.70) and TNF-${\alpha}$ (0.72) for CWP identification and progression, respectively, indicated the biomarker potential of the two cytokines. Serum cutoff values of IL-8 and TNF-${\alpha}$ were 11.63 pg/mL(sensitivity, 69%; specificity, 64%) and 4.52 pg/mL (sensitivity, 67%; specificity, 79%), respectively. Conclusion: The results suggest that high levels of serum IL-8 are associated with the presence of CWP and those of serum TNF-${\alpha}$ are associated with the progression of CWP.

#Anthracosis #Interleukin-8 #Tumor necrosis factor- ${alpha}$ #Receiver operating characteristic #Follow-up

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!