Evaluation of the analgesic and anti-inflammatory properties of methanol extract of Artanema sesamoides Benth roots in animal models

Gupta, Malaya; Mazumder, UK; Selvan, V Thamil; Manikandan, L; Senthilkumar, GP; Suresh, R; Gomathi, P; Kumar, B Ashok

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자료유형: 학술저널

저자정보: Gupta, Malaya (Department of Pharmaceutical Technology, Jadavpur University) Mazumder, UK (Department of Pharmaceutical Technology, Jadavpur University) Selvan, V Thamil (Department of Pharmaceutical Technology, Jadavpur University) Manikandan, L (Department of Pharmaceutical Technology, Jadavpur University) Senthilkumar, GP (Department of Pharmaceutical Technology, Jadavpur University) Suresh, R (Department of Pharmaceutical Technology, Jadavpur University) Gomathi, P (Department of Pharmaceutical Technology, Jadavpur University) Kumar, B Ashok (Department of Pharmaceutical Technology, Jadavpur University)

저널정보: 경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제8권 제2호

발행연도: 2008.1

수록면: 196 - 203 (8page)

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The methanol extract of the root of Artanema sesamoides Family Scrophuilariaceae (MEAS) was investigated for possible analgesic and anti-inflammatory effects in animals. Three models were used to study the extract effects on nociception, which were acetic acid-induced writhing response, hot-plate method and the tail flick test in mice. The antiinflammatory effects were evaluated using carrageenan, dextran, histamine and serotonin induced rat paw oedema (acute) and cotton pellet induced granuloma (chronic) models in rats. Results of the study revealed that the extract exhibited significant (P < 0.001) analgesic effect at a dose of 50, 100 and 200 mg/kg b.w p.o in mice in all the models. In acute model, the MEAS also exhibited significant (P < 0.001) antiinflammatory effect in all the above mentioned doses. In chronic model (cotton pellet induced granuloma) the MEAS 200 mg/kg and indomethacin 10 mg/kg showed that inhibition of granuloma formation 25.0% and 47.7% respectively (P < 0.001). The MEAS and indomethacin were effectively preventing the transudation of the fluid. Thus, the present study revealed that the methanol extract of the root of Artanema sesamoides exhibited significant analgesic and antiinflammatory activity.

#Antiinflammatory #Analgesic #Artanema sesamoides #Cotton pellet

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