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자료유형
학술저널
저자정보
Rahman, Shafiur (Pharmacy Discipline, Life Science School, Khulna University) Sarder, Mokaddez (Pharmacy Discipline, Life Science School, Khulna University) Shilpi, Jamil Ahmad (Pharmacy Discipline, Life Science School, Khulna University) Hasan, Choudhury Mahmud (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제6권 제4호
발행연도
2006.1
수록면
319 - 323 (5page)

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The crude ethanolic extract of the leaves of Clerodendrum viscosum (Family: Verbenaceae) was evaluated for its antioxidant and analgesic activities to investigate the scientific basis of the traditional uses. The antioxidant property of the extract was assessed by 1, 1-diphenyl -2- picryl hydrazyl (DPPH) free radical scavenging assay. The extract showed prominent antioxidant activity ($IC_{50}about{\sim}16{\mu}g/ml$) which was comparable to standard drug ascorbic acid ($IC_{50}about{\sim}15{\mu}g/ml$).The extract produced significant (P<0.001) writhing inhibition in acetic acid induced writhing in mice at the dose of 125 mg, 250 mg and 500 mg/kg body weight respectively, which were comparable to the standard drug diclofenac sodium. The results tend to suggest that the crude leaves extract at the above doses have antioxidant and analgesic activities and indicate that it might possess biologically active constituents having free radical scavenging and analgesic activities respectably.

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