지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 267 - 277 (11page)
이용수
초록· 키워드
오류제보하기
Benzene and ethylbenzene (BE), the volatile organic compounds (VOCs) are common constituents of cleaning and degreasing agents, paints, pesticides, personal care products, gasoline and solvents. VOCs are evaporated at room temperature and most of them exhibit acute and chronic toxicity to human. Chronic exposure of benzene is responsible for myeloid leukemia and also ethylbenzene is also recognized as a possible carcinogen. To evaluate the BE effect on human, whole human genome 35 K oligonucleotide microarray were screened for the identification of the differential expression profiling. We identified 280 up-regulated and 201 down-regulated genes changed by more than 1.5 fold by BE exposure. Functional analysis was carried out by using DAVID bioinformatics software. Clustering of these differentially expressed genes were associated with immune response, cytokine-cytokine receptor interaction, toll-like signaling pathway, small cell lung cancer, immune response, apoptosis, p53 signaling pathway and MAPKKK cascade possibly constituting alternative or subordinate pathways of hematotoxicity and immune toxicity. Gene ontology analysis methods including biological process, cellular components, molecular function and KEGG pathway thus provide a fundamental basis of the molecular pathways through BEs exposure in human lymphoma cells. This may provides a valuable information to do further analysis to explore the mechanism of BE induced hematotoxicity.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Differential Gene Expression Analysis in K562 Human Leukemia Cell Line Treated with Benzene
Toxicological Research
2011 .03
-
Functional Gene Analysis to Identify Potential Markers Induced by Benzene in Two Different Cell Lines, HepG2 and HL-60
Molecular & cellular toxicology
2008 .01
-
Gene Expression profiles of Ethylbenzene by microarray Analysis and Genetic Toxicity Test
환경독성보건학회 심포지엄 및 학술대회
2009 .05
-
Identification of VOCs-Induced Immune Responsive Genes in Human Promyelocytic Leukemia (HL-60) Cells
환경독성보건학회 심포지엄 및 학술대회
2006 .11
-
Exploration of Molecular Mechanisms of Diffuse Large B-cell Lymphoma Development Using a Microarray
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
Expression Profiling of Lipopolysaccharide Target Genes in RAW264.7 Cells by Oligonucleotide Microarray Analyses
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Profiling of remote skeletal muscle gene changes resulting from stimulation of atopic dermatitis disease in NC/Nga mouse model
The Korean Journal of Physiology & Pharmacology
2019 .01
-
Toxicogenomics Study on Benzene, Toluene and o-Xylene induced immune responsive genes in Human promyelocytic leukemia (HL-60) Cells
환경독성보건학회 심포지엄 및 학술대회
2006 .11
-
New Approaches to Functional Process Discovery in HPV 16-Associated Cervical Cancer Cells by Gene Ontology
Cancer Research and Treatment
2003 .01
-
皂角刺가 악성흑색종 세포주에 미치는 영향
한방안이비인후피부과학회지
2009 .01
-
Differential Gene Expression Induced by Naphthalene in Two Human Cell Line, HepG2 and HL-60
Molecular & cellular toxicology
2009 .01
-
Identification of Immune Responsive Genes on Benzene, Toluene and o-Xylene in Jurkat Cells Using 35 k Human Oligomicroarray
Molecular & cellular toxicology
2006 .01
-
Differentially Expressed Genes in Metastatic Advanced Egyptian Bladder Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Analysis of Key Genes and Pathways Associated with Colorectal Cancer with Microarray Technology
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
Gene Microarray Assessment of Multiple Genes and Signal Pathways Involved in Androgen-dependent Prostate Cancer Becoming Androgen Independent
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Gene Expression Profile and Its Interpretation in Squamous Cell Lung Cancer
Molecular & cellular toxicology
2006 .01
-
Toxicogenomics Study on Formaldehyde induced gene expression profiles in Human Promyelocytic Leukemia (HL-60) Cells
환경독성보건학회 심포지엄 및 학술대회
2006 .11
-
Microarray Analysis of Gene Expression Alteration in Human Middle Ear Epithelial Cells Induced by Asian Sand Dust
Clinical and Experimental Otorhinolaryngology
2015 .01
-
Toxicogenomics Study on Benzene, Toluene, o-Xylene and Formaldehyde (BTXF) Induced Gene Expression Profiles in Human Promyelocytic Leukemia (Hl-60) Cells
환경독성보건학회 심포지엄 및 학술대회
2007 .05
-
Gene Expression Profiling of Human Bronchial Epithelial (BEAS-2B) Cells Treated with Nitrofurantoin, a Pulmonary Toxicant
Molecular & cellular toxicology
2007 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0