지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 43 - 48 (6page)
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초록· 키워드
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Even though exposure to benzene has been linked to a variety of cancers including leukemia, the detailed molecular mechanisms relevant to benzene-induced carcinogenesis remain to be clearly elucidated. In this study, we evaluated the effects of benzene on differential gene expression in a leukemia cell line. The K562 leukemia cell line used in this study was cultured for 3 h with 10 mM benzene and RNA was extracted. To analyze the gene expression profiles, a 41,000 human whole genome chip was employed for cDNA microarray analysis. We initially identified 6,562 genes whose expression was altered by benzene treatment. Among these, 3,395 genes were upregulated and 3,167 genes were downregulated by more than 2-fold, respectively. The results of functional classification showed that the identified genes were involved in biological pathways including transcription, cell proliferation, the cell cycle, and apoptosis. These gene expression profiles should provide us with further insights into the molecular mechanisms underlying benzene- induced carcinogenesis, including leukemia.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (20)
참고문헌 신청
Garcia-Domingo, D. / 1999 / DIO-1 is a gene involved in onset of apoptosis in vitro, whosemisexpression disrupts limb development / Proc. Natl. Acad.Sci 96:7992~7997
Gutierrez, A. / 1997 / Inactivationof LEF1 in T-cell acuteHsu, S.Y., Kaipia, A., Zhu, L. and Hsueh, A.J. (1997). Interferenceof BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms andP11 / Mol. Endocrinol 11:1858~1867
Huff,J / 1999 / Long-term chemical carcinogenesis bioassays predicthuman cancer hazards. Issues, controversies, and uncertainties / Ann. NY. Acad. Sci 895:56~79
Joo, W.A. / 2003 / Monitoring protein expression by proteomics:human plasma exposed to benzene / Proteomics 3:2402~2411
Kozma, S.C / 2002 / Regulation of cell size ingrowth, development and human disease: PI3K, PKB and S6K / Bioessays 24:65~71
Gutierrez, A. / 1997 / Inactivationof LEF1 in T-cell acuteHsu, S.Y., Kaipia, A., Zhu, L. and Hsueh, A.J. (1997). Interferenceof BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms andP11 / Mol. Endocrinol 11:1858~1867
Huff,J / 1999 / Long-term chemical carcinogenesis bioassays predicthuman cancer hazards. Issues, controversies, and uncertainties / Ann. NY. Acad. Sci 895:56~79
Joo, W.A. / 2003 / Monitoring protein expression by proteomics:human plasma exposed to benzene / Proteomics 3:2402~2411
Kozma, S.C / 2002 / Regulation of cell size ingrowth, development and human disease: PI3K, PKB and S6K / Bioessays 24:65~71
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UCI(KEPA) : I410-ECN-0101-2012-513-004366337