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자료유형
학술저널
저자정보
Song, Jae-Hwi (Department of Pathology, College of Medicine, The Catholic University of Korea) Yoon, Jung-Hwan (Department of Pathology, College of Medicine, The Catholic University of Korea) Kang, Young-Hwi (Department of Pathology, College of Medicine, The Catholic University of Korea) Cao, Zhang (Department of Pathology, College of Medicine, The Catholic University of Korea) Nam, Suk-Woo (Department of Pathology, College of Medicine, The Catholic University of Korea) Lee, Jung-Young (Department of Pathology, College of Medicine, The Catholic University of Korea) Park, Won-Sang (Department of Pathology, College of Medicine, The Catholic University of Korea)
저널정보
대한독성유전단백체학회 Molecular & cellular toxicology Molecular & cellular toxicology 제5권 제4호
발행연도
2009.1
수록면
328 - 334 (7page)

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TBX3 has demonstrated oncogenic activity as a downstream target of the Wnt/$\beta$-catenin signaling pathway. In this study, the aim was to determine whether overexpression of the TBX3 protein is involved in the development and/or progression of gastric cancers. We analyzed the expression pattern of the TBX3 and $\beta$-catenin proteins in a series of 186 sporadic gastric cancers. Altered expression of the TBX3 and $\beta$-catenin proteins was observed in 54 (29.0%) and 48 (25.8%) of the 186 gastric cancers. Statistically, overexpression of the TBX3 and $\beta$-catenin proteins was not associated with the clinical and pathological parameters studied including: histological type, tumor location, tumor size, and the 5-year survival (P>0.05). However, TBX3 overexpression was closely associated with lymph node metastasis and aberrant $\beta$-catenin expression (P<0.05). In addition, overexpression of the TBX3 protein was confirmed by Western blot analysis of primary gastric cancer tissues and cell lines. These data suggest that TBX3 overexpression may play a role in the development and progression of sporadic gastric cancers.

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