Overexpression of Tbx3 Predicts Poor Prognosis of Patients with Resectable Pancreatic Carcinoma

Wang, Hong-Cheng; Meng, Qing-Cai; Shan, Ze-Zhi; Yuan, Zhou; Huang, Xin-Yu

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자료유형: 학술저널

저자정보: Wang, Hong-Cheng (Department of General Surgery, Sixth People's Hospital Affiliated Shanghai Jiao Tong University) Meng, Qing-Cai (Department of General Surgery, Sixth People's Hospital Affiliated Shanghai Jiao Tong University) Shan, Ze-Zhi (Department of General Surgery, Sixth People's Hospital Affiliated Shanghai Jiao Tong University) Yuan, Zhou (Department of General Surgery, Sixth People's Hospital Affiliated Shanghai Jiao Tong University) Huang, Xin-Yu (Department of General Surgery, Sixth People's Hospital Affiliated Shanghai Jiao Tong University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제4호

발행연도: 2015.1

수록면: 1,397 - 1,401 (5page)

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Background: To determine the expressions of Tbx3, a member of subgroup belonging to T-box family, and its prognostic value in pancreatic carcinoma. Materials and Methods: We determined the expression levels of Tbx3 on both mRNA and protein levels in 30 pairs of fresh tumor tissues and paratumor tissues by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting, respectively. In addition, protein level of Tbx3 were identified using immunochemistry in 80 pairs of paraffin-embedded specimen. The correlations between Tbx3 expression and various clinicopathological parameters as well as overall survival were evaluated. Results: Tbx3 mRNA and protein levels in tumor tissues were significantly higher than in the paratumor tissues by qRT-PCR ($0.05{\pm}0.007$ vs. $0.087{\pm}0.001$, p<0.001) and western blotting ($1.134{\pm}0.043$ vs. $0.287{\pm}0.017$, p<0.001). The statistical analysis based on immunohistochemical evaluation suggested that Tbx3 aberrant expression was significantly associated with several conventional clinicopathological variables, such as gender, age, tumor position, preoperative CA19-9 level, pathological T staging and N staging. Univariate and multivariate analyses revealed that Tbx3 expression was an independent prognostic factor for overall survival (<0.001). Conclusions: Our results suggest that overexpression of Tbx3 is associated with poor prognosis of pancreatic cancer patients. However, additional clinical trials are needed to accurately validate this observation.

#Tbx3 #pancreatic carcinoma #prognosis

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Wang, Hong-Cheng

소속기관 Department of General Surgery, Sixth People's Hospital Affiliated Shanghai Jiao Tong University