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논문 기본 정보

자료유형
학술저널
저자정보
Eom, Sung-Hwan (Korea Food Research Institute) Moon, Sun-Young (Department of Interdisciplinary Program of Biomedical Engineering, Pukyong National University) Lee, Dae-Sung (National Marine Biodiversity Institutes of Korea) Kim, Hyo-Jung (Department of Food Science and Technology, Pukyong National University) Park, Kunbawui (Food Safety Research Division, National Fisheries Research & Development Institute) Lee, Eun-Woo (Department of Life Science and Biotechnology, Dongeui University) Kim, Tae Hoon (Department of Food Science and Biotechnology, Daegu University) Chung, Yong-Hyun (Department of Ecological Engineering, Pukyong National University) Lee, Myung-Suk (Department of Microbiology, Pukyong National University) Kim, Young-Mog (Department of Food Science and Technology, Pukyong National University)
저널정보
한국조류학회(藻類) Algae Algae 제30권 제3호
발행연도
2015.1
수록면
241 - 246 (6page)

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This research was conducted to develop effective and safe marine-derived antiviral compounds against norovirus. The ethyl acetate (EtOAc)-extract from Eisenia bicyclis exhibited strong antiviral activity against murine norovirus (MNV) as a norovirus surrogate. Among the phlorotannins from E. bicyclis, dieckol (DE) and phlorofucofuroeckol-A (PFF) were known to possess the strongest antibacterial activity. In this study, DE and PFF were evaluated for antiviral activity against MNV. DE and PFF exhibited strong anti-MNV activity with 50% effective concentration ($EC_{50}$) of $0.9{\mu}M$. However, PFF exhibited more effective antiviral activity against MNV with higher selective index (668.87) than that of DE (550.60), due to its lower cell toxicity against RAW 264.7. This is the first report on the anti-MNV activity of phlorotannins from seaweed. The results obtained in this study suggest that the phlorotannins could be used as a potential source of natural antiviral agents.

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