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자료유형
학술저널
저자정보
Shim, Hyun-Soo (Department of Integrative Medicine, The Catholic University) Park, Hyun-Jung (Department of Integrative Medicine, The Catholic University) Kim, Kyung-Soo (Department of Integrative Medicine, The Catholic University) Hahm, Dae-Hyun (Acupuncture and Meridian Science Research Center, Kyung Hee University) Lee, Hye-Jung (Acupuncture and Meridian Science Research Center, Kyung Hee University) Shim, In-Sop (Acupuncture and Meridian Science Research Center, Kyung Hee University)
저널정보
대한동의생리학회 동의생리병리학회지 동의생리병리학회지 제24권 제2호
발행연도
2010.1
수록면
328 - 332 (5page)

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Acupuncture has been used for the treatment and prevention of stress-related disorders. In the present study, the effect of electroacupuncture on the behavioral and biochemical responses to restraint stress was evaluated in rats. Sprague-Dawley male rats underwent to immobilization stress for 21 days (6 hours/day). Electroacupuncture (2 Hz, 2 mA, and 10 minutes) was applied either to the acupuncture point HT7 (Shenmen) or the nonacupuncture point in the tail for the last 7 days. Rats were randomly divided into four groups: the normal group (n=10, without the restraint stress), the stress group (n=10, with restraint stress), the HT7 group (n=10, with restraint stress and electroacupuncture to HT7), and the NA group (n=10, with restraint stress and electroacupuncture to the nonacupuncture point). The anxiety-related behavior was tested using the elevated plus maze and the Vogel test on day 22. The expression of tyrosine hydroxylase in the locus coeruleus was measured by immunohistochemistry. R maze and the Vogecreased the response of the anxiety-related behavior. The number of tyrosine hydroxylase-immunoreactive cells were also increased. The HT7 group showed a significant decrease of anxiety-related behavioral response, compared to the stress group. The tyrosine hydroxylase-immunoreactive expression was also decreased in the HT7 group. These findings suggestthat electroacupuncture to HT7 might play a role in reducing the stress-related responses, which may be helpful for the treatment of stress-related disorders.

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