Genotyping of Peroxisome Proliferator-Activated Receptor gamma in Iranian Patients with Helicobacter pylori Infection

Goudarzi, Hossein; Seyedjavadi, Sima Sadat; Fazeli, Maryam; Azad, Mehdi; Goudarzi, Mehdi

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저자정보: Goudarzi, Hossein (Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Science) Seyedjavadi, Sima Sadat (Department of Pharmaceutical Biotechnology, Pasteur institute) Fazeli, Maryam (Department of Virology, Faculty of Medicine, Tarbiat Modares University) Azad, Mehdi (Department of Medical laboratory sciences, School of Paramedicine, Qazvin University of Medical Sciences) Goudarzi, Mehdi (Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Science)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제13호

발행연도: 2015.1

수록면: 5,219 - 5,223 (5page)

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Helicobacter pylori (H. pylori) infection as a serious problem in both adults and children can induce chronic gastritis, peptic ulcer disease (PUD), and possibly gastric cancer. The aim of the current study was to survey antibiotic resistance and also to determine influence of PPAR$\gamma$ polymorphism in patients with H. pylori infection. During an 11-month-period, 98 H. pylori isolates were collected from 104 biopsy specimens. In vitro susceptibility of H. pylori isolates to 4 antimicrobial agents metronidazole, clarithromycin, amoxicillin and tetracycline were assessed by quantitative method according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) guideline. PPAR$\gamma$ polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism assay. The frequency of H. pylori infection in our study was 94.2%. In vitro susceptibility data showed that highest level of resistance was related to metronidazole (66.3%), and the majority of H. pylori isolates were highly susceptible to amoxicillin and tetracycline (94.9% and 96.9%, respectively). Genotypic frequencies were 25.5% for CC (Pro12Pro), 40.8% for GC (Pro12Ala) and 33.7% for GG (Ala12Ala). In our study, CG genotype had highest distributions among infected patients with H. pylori. The study suggests that the PPAR-$\gamma$ Pro12Ala polymorphism could be evaluated as a potential genetic marker for susceptibility to gastric cancer in the presence of H. pylori infection.

#Peroxisome proliferator-activated receptor $gamma$ #Helicobacter pylori #gastric cancer

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Goudarzi, Hossein

소속기관 Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences