PLCE1 Gene in Esophageal Cancer and Interaction with Environmental Factors

Guo, Li-Yan; Zhang, Shen; Suo, Zhen; Yang, Chang-Shuang; Zhao, Xia; Zhang, Guo-An; Hu, Die; Ji, Xing-Zhao; Zhai, Min

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자료유형: 학술저널

저자정보: Guo, Li-Yan (Department of Public Health, Jining Medical University) Zhang, Shen (Department of Cardio-Thoracic Surgery, The first people's hospital of Jining city) Suo, Zhen (Department of pharmacy, Ankang hospital of Shandong province) Yang, Chang-Shuang (Department of Public Health, Jining Medical University) Zhao, Xia (Department of Cardio-Thoracic Surgery, The first people's hospital of Jining city) Zhang, Guo-An (School of Basic Medical Science, Jining Medical University) Hu, Die (Department of Public Health, Jining Medical University) Ji, Xing-Zhao (Department of Public Health, Jining Medical University) Zhai, Min (Department of Public Health, Jining Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제7호

발행연도: 2015.1

수록면: 2,745 - 2,749 (5page)

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Objective: To study the PLCE1 gene rs2274223 polymorphism with regard to esophageal cancer and its interaction with diet, lifestyle, psychological and environmental factors in Southwest Shandong province. Materials and Methods: A case series study (case-case) was conducted. Questionnaire data were collected and 3 ml-5ml venous blood was drawn for DNA extraction among the qualified research subjects. PLCE1 gene polymorphism was detected after PCR amplification of DNA. SPSS 13.0 software was used for statistical analysis of the data. Results: The three genotypes A/A, A/G and G/G PLCE1 gene rs2274223 was 31, 16 and 4 cases, accounting for 60.8%, 31.4%, 0.08% respectively. The difference of three genotypes (AA/GA/GG) proportion between negative and positive family history of patients was statistically significant, ${\chi}^2=6.213$, p=0.045. There was no statistically significant relationship between PLCE1 gene rs2274223 polymorphism and smoking, drinking, ${\chi}^2=0.119$, p=0.998, and ${\chi}^2=1.727$, p=0.786. There was no linkage of the three rs2274223 PLCE1 gene genotypes (AA/GA/GG) proportion with eating fried, pickled, hot, mildew, overnight, smoked, excitant food, eat speed, salt taste or not (p>0.05). or with living environment pollution and nine risk factors of occupational exposure (p>0.05). There was no statistically significant difference in TS scores between different genotype of rs2274223 PLCE1 gene. Conclusions: The PLCE1 rs2274223 polymorphism has a relationship with family history of esophageal cancer, but does not have any significant association with age, gender, smoking, alcohol drinking, food hygiene, eating habits, living around the environment and occupation in cases.

#Esophageal carcinoma #PLCE1 gene #case series study #gene polymorphism #interaction

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