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논문 기본 정보

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학술저널
저자정보
Liu, Zhong (Medical College, Qingdao University) Wang, Xin-Mei (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital) Jia, Tong-Fu (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital) Zhai, Yi (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital) Sun, Ling-Yan (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital) Cheng, Yu-Ping (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital) Zhang, Yue-Min (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital) Liu, Shi-Hai (Department of Medical Research Center, Department of Oncology, the Affiliated Hospital of Qingdao University) Liang, Jun (Department of Medical Research Center, Department of Oncology, the Affiliated Hospital of Qingdao University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제2호
발행연도
2015.1
수록면
679 - 682 (4page)

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Background: Studies indicate the immediate early response gene 3 (IER3) is involved in many biological processes. Recently, it was discovered that IER3 plays an important role in tumorigenesis and tumor progression. Thus it may be a valuable biomarker in tumor. This study was designed to investigate the expression status of IER3 in primary hepatocarcinoma (PHC) and correlation with clinicopathological parameters. Materials and Methods: Real-time PCR was performed to evaluate the expression levels of IER3 in 62 pathologically diagnosed human PHC specimens. Results: A statistically significant association was disclosed between the expression of IER3 and P53 mutant protein (short for P53), Ki-67, EGFR and the biggest diameter, differentiation grade of tumor. Conclusions: This work is the first to shed light on the potential clinical usefulness of IER3, as an efficient tumor biomarker in PHC.

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