Mutation Detection of E6 and LCR Genes from HPV 16 Associated with Carcinogenesis

Mosmann, Jessica P.; Monetti, Marina S.; Frutos, Maria C.; Kiguen, Ana X.; Venezuela, Raul F.; Cuffini, Cecilia G.

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자료유형: 학술저널

저자정보: Mosmann, Jessica P. (Instituto de Virologia "Dr. J. M. Vanella", Facultad de Ciencias Medicas-Universidad Nacional de Cordoba) Monetti, Marina S. (Instituto de Virologia "Dr. J. M. Vanella", Facultad de Ciencias Medicas-Universidad Nacional de Cordoba) Frutos, Maria C. (Instituto de Virologia "Dr. J. M. Vanella", Facultad de Ciencias Medicas-Universidad Nacional de Cordoba) Kiguen, Ana X. (Instituto de Virologia "Dr. J. M. Vanella", Facultad de Ciencias Medicas-Universidad Nacional de Cordoba) Venezuela, Raul F. (Instituto de Virologia "Dr. J. M. Vanella", Facultad de Ciencias Medicas-Universidad Nacional de Cordoba) Cuffini, Cecilia G. (Instituto de Virologia "Dr. J. M. Vanella", Facultad de Ciencias Medicas-Universidad Nacional de Cordoba)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제3호

발행연도: 2015.1

수록면: 1,151 - 1,157 (7page)

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Human papillomavirus (HPV) is responsible for one of the most frequent sexually transmitted infections. The first phylogenetic analysis was based on a LCR region fragment. Nowadays, 4 variants are known: African (Af-1, Af-2), Asian-American (AA) and European (E). However the existence of sub-lineages of the European variant havs been proposed, specific mutations in the E6 and LCR sequences being possibly related to persistent viral infections. The aim of this study was a phylogenetic study of HPV16 sequences of endocervical samples from C${\acute{o}}$rdoba, in order to detect the circulating lineages and analyze the presence of mutations that could be correlated with malignant disease. The phylogenetic analysis determined that 86% of the samples belonged to the E variant, 7% to AF-1 and the remaining 7% to AF-2. The most frequent mutation in LCR sequences was G7521A, in 80% of the analyzed samples; it affects the binding site of a transcription factor that could contribute to carcinogenesis. In the E6 sequences, the most common mutation was T350G (L83V), detected in 67% of the samples, associated with increased risk of persistent infection. The high detection rate of the European lineage correlated with patterns of human migration. This study emphasizes the importance of recognizing circulating lineages, as well as the detection of mutations associated with high-grade neoplastic lesions that could be correlated to the development of carcinogenic lesions.

#HPV 16 #lineages #mutations #E6 #LCR #cervical cancer

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