Comparison of Serum Fucose Levels in Leukoplakia and Oral Cancer Patients

Rai, Narendra Prakash; Anekar, Jayaprasad; Shivaraja, Shankara YM; Divakar, Darshan Devang; Al Kheraif, Abdulaziz Abdullah; Ramakrishnaiah, Ravikumar; Sebastian, Roopa; Raj, AC; Al-Hazmi, Ali; Mustafa, habil Mohamed

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자료유형: 학술저널

저자정보: Rai, Narendra Prakash (Department of Oral Medicine & Radiology, Lincoln's University College) Anekar, Jayaprasad (KVG Dental College & Hospital Sullia) Shivaraja, Shankara YM (Department of Biochemistry, KVG Medical College & Hospital Sullia) Divakar, Darshan Devang (Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University) Al Kheraif, Abdulaziz Abdullah (Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University) Ramakrishnaiah, Ravikumar (Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University) Sebastian, Roopa (Department of Biochemistry, KVG Medical College & Hospital Sullia) Raj, AC (KVG Dental College & Hospital Sullia) Al-Hazmi, Ali (Department of Family & Community Medicine, King Saud University) Mustafa, habil Mohamed (Malabar Dental College and Research Centre)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제17호

발행연도: 2015.1

수록면: 7,497 - 7,500 (4page)

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Background: Tumor markers, designated as a broad group of substances produced by malignancies, could be in the form of biochemical substances, immunological substances, cell surface changes and genetic alterations. Cancer, a disorder of cellular behavior is characterized by alteration of serum glycoproteins. L-fucose, a hexose, which is the terminal sugar in most of the plasma glycoproteins, may be useful as a tumor marker for the detection, monitoring and prognostic assessment of malignancies. The aim of the study was to ascertain the role of serum fucose as a biomarker for early detection of oral cancer and to compare serum fucose levels in healthy controls, leukoplakia and oral cancer patients. Materials and Methods: The study included 60 (100.0%) subjects, who were grouped as 20 (33.3%) control subjects, 20 (33.3%) squamous cell carcinoma patients and 20 (33.3%) leukoplakia patients. Fucose estimation was done using UV-visible spectrophotometry based on the method as adopted by Winzler using cysteine reagent. The results were analyzed statistically using ANOVA with Bonferroni post hoc tests. Results: Results showed a high significance in serum fucose in oral squamous cell carcinoma (OSCC) and leukoplakia subjects compared to normal controls. There was a gradual increase in the values noted from control to leukoplakia and to squamous cell carcinoma. Conclusions: Estimation of serum fucose may be a reliable marker and can be used as an effective diagnostic biomarker in oral squamous cell carcinoma patients.

#Cancer #leukoplakia #oral squamous cell carcinoma #OSCC) #serum fucose

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