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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 324 - 330 (7page)
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Objectives: There are only a limited number of studies on cyclin D1 and p63 expression in oral squamous cell carcinoma (OSCC) and leukoplakia. This study compared cyclin D1 and p63 expression in leukoplakia and OSCC to investigate the possible correlation of both markers with grade of dys-plasia and histological grade of OSCC. Materials and Methods: The study included a total of 60 cases, of which 30 were diagnosed with OSCC and 30 with leukoplakia, that were evalu-ated immunohistochemically for p63 and cyclin D1 expression. Protein expression was correlated based on grades of dysplasia and OSCC. Results: Out of 30 cases of OSCC, 23 cases (76.7%) were cyclin D1 positive and 30 cases (100%) were p63 positive. Out of 30 cases of leukoplakia, 21 cases (70.0%) were cyclin D1 positive and 30 (100%) were p63 positive (P<0.05). Conclusion: The overall expression of cyclin D1 and p63 correlated with tumor differentiation, and increases were correlated with poor histological grades, from well-differentiated to poorly-differentiated SCC. Increased cyclin D1 and p63 expression was associated with the severity of leukoplakia. Based on these results cyclin D1 and p63 products can be a useful tool for improved leukoplakia prognosis.
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참고문헌 (24)
참고문헌 신청
Angadi PV / 2007 / Cyclin D1 expression in oral squamous cell carcinoma and verrucous carcinoma: correlation with histological differentiation / Oral Surg Oral Med Oral Path
Bartkova J / 1994 / Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein / J Pathol 172 : 237 ~ 245
Bortoluzzi MC / 2004 / Assessment of p63 expression in oral squamous cell carcinomas and dysplasias / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98 : 698 ~ 704
Castle JT / 1999 / P53 and cyclin D1 staining patterns of malignant and premalignant oral lesions in age-dependent populations / Oral Surg Oral Med Oral Pathol Oral Radiol En
Chen YK / 2005 / Expression of p63 protein and mRNA in oral epithelial dysplasia / J
Bartkova J / 1994 / Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein / J Pathol 172 : 237 ~ 245
Bortoluzzi MC / 2004 / Assessment of p63 expression in oral squamous cell carcinomas and dysplasias / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98 : 698 ~ 704
Castle JT / 1999 / P53 and cyclin D1 staining patterns of malignant and premalignant oral lesions in age-dependent populations / Oral Surg Oral Med Oral Pathol Oral Radiol En
Chen YK / 2005 / Expression of p63 protein and mRNA in oral epithelial dysplasia / J
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