Evaluation of BCL6 and MUM1 Expression in Patients with Diffuse Large B cell Lymphoma and their Correlations with Staging and Prognosis in Iran

Rahimi, Hossein; Jafarian, Amirhossein; Samadi, Alireza; Meamar, Bahram; Rahmani, Shaghayegh

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자료유형: 학술저널

저자정보: Rahimi, Hossein (Hematology Oncology Department, Mashhad University of Medical Science) Jafarian, Amirhossein (Pathology Department, Cancer and Molecular Pathology Research Center, Mashhad University of Medical Science) Samadi, Alireza (Internal Medicine Research Center for Patient Safety, Mashhad University of Medical Science) Meamar, Bahram (Pathology, Cancer Research Center, Mashhad University of Medical Science) Rahmani, Shaghayegh (Research Center for Patient Safety, Mashhad University of Medical Science)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제1호

발행연도: 2015.1

수록면: 83 - 86 (4page)

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Background: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkins lymphoma (NHL), accounting for approximately 25% of NHL cases. The aim of this study was to evaluate the association between the BCL6 and MUM1 gene expression and patient prognosis and stage. Materials and Methods: After ethical approval, in a cross-sectional study, tissue samples of 80 patients with diffuse large B-cell lymphoma were analyzed for BCL6 and MUM1 gene expression. Immunohistochemical staining was performed with division into categories of 0-5%, 5-25%, 26-50%, 51-75% and more than 75%. Other clinical and histological information such as lymph node involvement, T-stage, B symptoms and patient outcome were also recorded. Data were analyzed with SPSS version 16 and a P-value less than 0.05 was considered significant. Results: The patient mean age was $46.9{\pm}10.5$ years ($47.6{\pm}10.7$ and $46.1{\pm}9.6$ for males and females, respectively). A significant association was seen between lymphoma stage and BCL6 (p=0.045) but not MUM1 expression (p=0.09). However, the latter was associated with mortality (p=0.006) as was also the BCL6 level (p=0.006). Conclusions: : Overexpression of MUM1 and BCL6 is associated with poor prognosis in patients with diffuse large B-cell lymphoma.

#Diffuse large B-cell lymphoma #MUM1 #BCL6 #prognosis #Iran

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