Association between RASSF1A Promoter Hypermethylation and Oncogenic HPV Infection Status in Invasive Cervical Cancer: a Meta-analysis

Li, Jin-Yun; Huang, Tao; Zhang, Cheng; Jiang, Dan-Jie; Hong, Qing-Xiao; Ji, Hui-Hui; Ye, Meng; Duan, Shi-Wei

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자료유형: 학술저널

저자정보: Li, Jin-Yun (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) Huang, Tao (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) Zhang, Cheng (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) Jiang, Dan-Jie (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) Hong, Qing-Xiao (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) Ji, Hui-Hui (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University) Ye, Meng (The Affiliated Hospital, Ningbo University) Duan, Shi-Wei (Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제14호

발행연도: 2015.1

수록면: 5,749 - 5,754 (6page)

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Cervical carcinoma is the main cause of cancer-related mortality in women and is correlated with more than 15 risk cofactors, including infection of cervical cells with high-risk types of HPV (hrHPV). Indeed, both aberrant methylation of the RASSF1A promoter and hrHPV infection are often observed in cervical carcinomas. The purpose of our meta-analysis was to evaluate the role of RASSF1A promoter methylation and hrHPV infection in cervical cancer. Our meta-analysis involved 895 cervical cancer patients and 454 control patients from 15 studies. Our results suggested that RASSF1A promoter hypermethylation increased the risk of cervical cancer (OR=9.77, 95%CI=[3.06, 31.26], P=0.0001, $I^2=78%$). By grouping cases according to cancer subtypes, we found that HPV infection was higher in cervical squamous cell carcinomas (SCCs) than in cervical adenocarcinomas/adenosquamous cancers (ACs/ASCs) (OR=4.00, 95%CI=[1.41, 11.30], P=0.009, $I^2=55%$). Interestingly, HPV infection tended to occur in cervical cancers with relatively low levels of RASSF1A promoter methylation (OR=0.59, 95%CI=[0.36, 0.99], P=0.05, I2=0%). Our study provides evidence of a possible interaction between HPV infection and RASSF1A promoter methylation in the development of cervical cancers.

#Cervical cancer #RASSF1A methylation #human papilloma virus #HPV infection #meta-analysis

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Li, Jin-Yun

소속기관 Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University