Evaluation of Several Screening Approaches for Detection of Cervical Lesions in Rural Shandong, China

Zong, Li-Ju; Zhang, You-Zhong; Yang, Xing-sheng; Jiang, Jie; Cui, Bao-Xia; Qiao, Yun-Bo; Li, Li; Jiang, Kan; Zhang, Wen-Jing; Kong, Bei-Hua; Shen, Keng

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자료유형: 학술저널

저자정보: Zong, Li-Ju (Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University) Zhang, You-Zhong (Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University) Yang, Xing-sheng (Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University) Jiang, Jie (Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University) Cui, Bao-Xia (Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University) Qiao, Yun-Bo (Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University) Li, Li (Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University) Jiang, Kan (Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University) Zhang, Wen-Jing (Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University) Kong, Bei-Hua (Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University) Shen, Keng (Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제5호

발행연도: 2015.1

수록면: 1,907 - 1,912 (6page)

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Purpose: The study was designed to: (1) investigate the prevalence of high-risk human papillomavirus (HR-HPV) infection and cervical neoplasia; and (2) evaluate clinical performance of visual inspection with acetic acid/ Lugol's iodine (VIA /VILI), Pap smear, high-risk human papillomavirus (HR-HPV) DNA test for detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and (3) explore appropriate screening approach in rural areas of Shandong Province. Materials and Methods: A total of 3,763 eligible women from Yiyuan County in Yimeng mountainous areas of rural Shandong, China, were enrolled and underwent Pap smear, HR-HPV DNA testing by Hybrid Capture 2 (HC2), and VIA /VILI tests. Women positive in any test were referred to colposcopy and biopsy as indicated. Results: The prevalence of HR-HPV infection among all enrolled women was 11.1% and that in healthy women was 9.9%. In total 33 cases of CIN1, 16 cases of CIN2, 6 cases of CIN3 but none of cervical cancer were detected and the crude prevalence of CIN2+ was 0.58%. For detecting CIN2+, the sensitivity of HR-HPV DNA testing, VIA/VILI, Pap smear was 90.9%, 77.3%, 81.8%, respectively. Pap smear had the best specificity of 98.2%, followed by HR-HPV DNA testing with specificity of 89.4%, VIA/VILI had the lowest specificity of 81.2%. Colposcopy referral rate of HR-HPV DNA testing, VIA/VILI, Pap smear was 11.1%, 18.5%, 2.3%, respectively. Conclusions: Our results suggest that HR-HPV DNA testing alone might be appropriate for primary cervical cancer screening in rural low-resource areas of Shandong Province, China.

#Cervical cancer screening #high-risk human papillomavirus DNA #rural areas #Shandong, China

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