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자료유형
학술저널
저자정보
Moon, Kyoung Min (Division of Pulmonology, Department of Internal Medicine, Eulji University School of Medicine) Han, Min Soo (Division of Pulmonology, Department of Internal Medicine, Eulji University School of Medicine) Chung, So Hee (Division of Pulmonology, Department of Internal Medicine, Eulji University School of Medicine) Kim, Ju Ri (Division of Pulmonology, Department of Internal Medicine, Eulji University School of Medicine) Kim, Jin Young (Division of Pulmonology, Department of Internal Medicine, Eulji University School of Medicine) Jung, Sun Young (Division of Pulmonology, Department of Internal Medicine, Eulji University School of Medicine) Cho, Yongseon (Division of Pulmonology, Department of Internal Medicine, Eulji University School of Medicine)
저널정보
대한결핵 및 호흡기학회 Tuberculosis and Respiratory Diseases 결핵 및 호흡기 질환 제78권 제2호
발행연도
2015.1
수록면
125 - 127 (3page)

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We report a case of agranulocytosis caused by ethambutol in a 79-year-old man with pulmonary tuberculosis. He was referred for fever and skin rash developed on 21th day after antituberculosis drugs (isoniazid, rifampicin, ethambutol, and pyrazinamide) intake. Complete blood count at the time of diagnosis of pulmonary tuberculosis was normal. On the seventh admission day, agranulocytosis was developed with absolute neutrophil count of $70/{\mu}L$. We discontinued all antituberculosis drugs, and then treated with granulocyte colony-stimulating factor. Three days later, the number of white blood cell returned to normal. We administered isoniazid, pyrazinamide, and ethambutol in order with an interval. However, fever and skin rash developed again when adding ethambutol, so we discontinued ethambutol. After these symptoms disappeared, we added rifampicin and ethambutol in order with an interval. However after administering ethambutol, neutropenia developed, so we discontinued ethambutol again. He was cured with isoniazid, rifampicin, and pyrazinamide for 9 months.

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