Prevalence and Associated Factors of Abnormal Cervical Cytology and High-Risk HPV DNA among Bangkok Metropolitan Women

Tangjitgamol, Siriwan; Kantathavorn, Nuttavut; Kittisiam, Thannaporn; Chaowawanit, Woraphot; Phoolcharoen, Natacha; Manusirivithaya, Sumonmal; Khunnarong, Jakkapan; Srijaipracharoen, Sunamchok; Saeloo, Siriporn; Krongthong, Waraporn; Supawattanabodee, Busaba; Thavaramara, Thaovalai; Pataradool, Kamol

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자료유형: 학술저널

저자정보: Tangjitgamol, Siriwan (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) Kantathavorn, Nuttavut (Section of Obstetrics and Gynecology, Chulabhorn Hospital) Kittisiam, Thannaporn (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) Chaowawanit, Woraphot (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) Phoolcharoen, Natacha (Section of Obstetrics and Gynecology, Chulabhorn Hospital) Manusirivithaya, Sumonmal (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) Khunnarong, Jakkapan (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) Srijaipracharoen, Sunamchok (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) Saeloo, Siriporn (Data Management Unit, Chulabhorn Hospital) Krongthong, Waraporn (Data Management Unit, Chulabhorn Hospital) Supawattanabodee, Busaba (Research Facilitation Unit, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) Thavaramara, Thaovalai (Department of Obstetrics and Gynecology, Faculty) Pataradool, Kamol

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제7호

발행연도: 2016.1

수록면: 3,147 - 3,153 (7page)

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Background: Many strategies are required for cervical cancer reduction e.g. provision of education cautious sexual behavior, HPV vaccination, and early detection of pre-invasive cervical lesions and invasive cancer. Basic health data for cervical cytology/ HPV DNA and associated factors are important to make an appropriate policy to fight against cervical cancer. Aims: To assess the prevalence of abnormal cervical cytology and/or HPV DNA and associated factors, including sexual behavior, among Bangkok Metropolitan women. Materials and Methods: Thai women, aged 25-to-65 years old, had lived in Bangkok for ${\geq}5$ years were invited into the study. Liquid-based cervical cytology and HPV DNA tests were performed. Personal data were collected. Main Outcomes Measures: Rates of abnormal cytology and/ or high-risk HPV (HR-HPV) and factors associated with abnormal test (s) were studied. Results: Abnormal cytology and positive HR-HPV were found in 6.3% (279/4442 women) and 6.7% (295/4428), respectively. The most common abnormal cytology was ASC-US (3.5%) while the most common HR-HPV genotype was HPV 16 (1.4%) followed by HPV 52 (1.0%), HPV 58 (0.9%), and HPV 18 and HPV 51 at equal frequency (0.7%). Both tests were abnormal in 1.6% (71/4428 women). Rates of HR-HPV detection were directly associated with severity of abnormal cytology: 5.4% among normal cytology and 13.0%, 30.8%, 40.0%, 39.5%, 56.3% and 100.0% among ASC-US, ASC-H, AGC-NOS, LSIL, HSIL, and SCC, respectively. Some 5% of women who had no HR-HPV had abnormal cytology, in which 0.3% had ${\geq}$ HSIL. Factors associated with abnormal cytology or HR-HPV were: age ${\leq}40$ years, education lower than (for cytology) or higher than bachelor for HR-HPV), history of sexual intercourse, and sexual partners ${\geq}2$. Conclusions: Rates for abnormal cytology and HR-HPV detection were 6.3% and 6.7% HR-HPV detection was directly associated with severity of abnormal cytology. Significant associated factors were age ${\leq}40$ years, lower education, history of sexual intercourse, and sexual partners ${\geq}2$.

#Abnormal cervical cytology #high-risk HPV #education #sexual behavior

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Tangjitgamol, Siriwan

소속기관 Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj Unive