Growth Hormone 1 T1663A Polymorphism, Recreational Physical Activity and BMI, and Breast Cancer Risk in Chinese Women

Gao, Chang-Ming; Ding, Jian-Hua; Wu, Jian-Shong; Cao, Hai-Xia; Li, Su-Ping; Liu, Yan-Ting; Tang, Jin-Hai; Tajima, Kazuo

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자료유형: 학술저널

저자정보: Gao, Chang-Ming (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) Ding, Jian-Hua (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) Wu, Jian-Shong (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) Cao, Hai-Xia (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) Li, Su-Ping (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) Liu, Yan-Ting (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) Tang, Jin-Hai (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) Tajima, Kazuo (Dept. of Public Health & Occupational Medicine, Mie University Graduate School of Medicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제13호

발행연도: 2015.1

수록면: 5,421 - 5,425 (5page)

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To evaluate the relationship between the growth hormone 1 (GH1) T1663A polymorphism, recreational physical activity and body mass index (BMI) with reference to breast cancer, we conducted a case-control study with 669 cases of breast cancer and 682 population-based controls in Jiangsu Province, China. A structured questionnaire was used to elicit detailed information. All subjects completed an in-person interview. GH1 genotypes were identified using PCR-RFLP methods. Odds ratios (ORs) were estimated with an unconditional logistic model. The distribution of GH1 genotypes was not significantly different between controls and cases ($x^2$=2.576, P=0.276). Results of stratified analysis by the participation status of the recreational physical activity showed that the persons with GH1 A allele were at a decreased risk of breast cancer (adjusted-OR=0.66; 95% CI, 0.50-0.87) only among inactive individuals. Stratified analysis by BMI showed that the genotype A/A was associated with a decreased risk of breast cancer only among individuals of the BMI <25 (adjusted-OR=0.80; 95% CI, 0.66-0.98). The findings of this study suggest that recreational physical activity and BMI may modify any association between the GH1 T1663A polymorphism and breast cancer risk.

#Breast cancer #GH1 genetic polymorphism #recreational physical activity #BMI

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