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논문 기본 정보

자료유형
학술저널
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Byun, Hwa Kyung (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) Yoon, Hong In (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) Cho, Jaeho (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) Kim, Hyun Ju (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) Min, Yoo Hong (Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine) Lyu, Chuhl Joo (Division of Pediatric Hemato-oncology, Department of Pediatrics, Yonsei University Health System, Yonsei University College of Medicine) Cheong, June-Won (Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine) Kim, Jin Seok (Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine) Kim, Hyo Sun (Division of Pediatric Hemato-oncology, Department of Pediatrics, Yonsei University Health System, Yonsei University College of) Kim, Soo-Jeong Yang, Andrew Jihoon Lee, Byung Min Lee, Won Hee Lee, Joongyo Ahn, Ki Jung Suh, Chang-Ok
저널정보
대한방사선종양학회 Radiation oncology journal : ROJ Radiation oncology journal : ROJ 제35권 제3호
발행연도
2017.1
수록면
257 - 267 (11page)

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Purpose: Pulmonary toxicities, including infectious pneumonia (IP) and idiopathic pneumonia syndrome (IPS), are serious side effects of total body irradiation (TBI) used for myeloablative conditioning. This study aimed to evaluate clinical factors associated with IP and IPS following TBI. Materials and Methods: Fifty-eight patients with hematologic malignancies who underwent TBI before allogeneic hematopoietic stem cell transplantation between 2005 and 2014 were reviewed. Most patients (91%) received 12 Gy in 1.5 Gy fractions twice a day. Pulmonary toxicities were diagnosed based on either radiographic evidence or reduced pulmonary function, and were subdivided into IP and IPS based on the presence or absence of concurrent infection. Results: Pulmonary toxicities developed in 36 patients (62%); 16 (28%) had IP and 20 (34%) had IPS. IP was significantly associated with increased treatment-related mortality (p = 0.028) and decreased survival (p = 0.039). Multivariate analysis revealed that the risk of developing IPS was significantly higher in patients who received stem cells from a matched unrelated donor than from a matched sibling donor (p = 0.021; hazard ratio [HR] = 12.67; 95% confidence interval [CI], 1.46-110.30). Combining other conditioning agents with cyclophosphamide produced a higher tendency to develop IP (p = 0.064; HR = 6.19; 95% CI, 0.90-42.56). Conclusion: IP and IPS involve different risk factors and distinct pathogeneses that should be considered when planning treatments before and after TBI.

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