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논문 기본 정보

자료유형
학술저널
저자정보
Woo, Jinhee (Department of Physical Education, College of Arts and Physical Education, Dong-A University) Shin, Ki-Ok (Department of Physical Education, College of Arts and Physical Education, Dong-A University) Park, Chan-Ho (Department of Leisure and Sport, Dong-Eui University) Yoon, Byung-Kon (Department of Physical Education, Dong-Eui University) Kim, Do-Yeon (Department of Physical Education, Pusan National University) Bae, Ju-Yong (Department of Physical Education, College of Arts and Physical Education, Dong-A University) Lee, Yul-Hyo (Department of Physical Education, College of Arts and Physical Education, Dong-A University) Ko, Kangeun (Department of Physical Education, College of Arts and Physical Education, Dong-A University) Roh, Hee-Tae (Department of Physical Education, College of Arts and Physical Education, Dong-A University)
저널정보
한국유화학회 한국유화학회지 한국응용과학기술학회지 제36권 제3호
발행연도
2019.1
수록면
804 - 812 (9page)

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The purpose of this study was to investigate the effects of different types of exercise training on neurodegeneration and cognitive function in mice with impaired glucose tolerance (IGT). Thirty-six male C57BL/6 mice were randomly assigned to the control (CO, n = 9) and impaired glucose tolerance (IGT, n = 27) groups. The IGT group consumed 45% high fat diet for 4 weeks and received 40 mg/kg of streptozotocin twice in the lower abdomen to induce IGT. After the IGT induction period, the IGT group was subdivided into IGT + sedentary (IGT, n = 9), IGT + endurance exercise (IGTE, n = 9), and IGT + resistance exercise (IGTR, n = 9). The IGTE and IGTR groups performed treadmill and ladder climbing exercises 5 times per week for 8 weeks, respectively. Fasting glucose and glycated hemoglobin (HbA1c) levels were significantly higher in IGT group than in CO, IGTE, and IGTR groups (p < 0.05). HOMA-IR was significantly higher in IGT group than CO group (p < 0.05). Hippocampal catalase (CAT) was significantly lower in IGT group than in CO group (p < 0.05), while beta-amyloid ($A{\beta}$) was significantly higher in IGT group than in CO group (p < 0.05). Hippocampal tau was significantly higher in IGT group than in CO, IGTE, and IGTR groups (p < 0.05). The Y-maze test performance for cognitive function was significantly lower in IGT group than in CO, IGTE, and IGTR groups (p <0.05). These results suggest that IGT induces neurodegeneration and negatively affects cognitive function, while regular exercise may be effective in alleviating neurodegeneration and cognitive decline regardless of exercise type.

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