The effects of blastocyst morphological score and blastocoele re-expansion speed after warming on pregnancy outcomes

Yin, Huiqun; Jiang, Hong; He, Ruibing; Wang, Cunli; Zhu, Jie; Li, Yang

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자료유형: 학술저널

저자정보: Yin, Huiqun (Reproductive Medicine Center) Jiang, Hong (Reproductive Medicine Center) He, Ruibing (Reproductive Medicine Center) Wang, Cunli (Reproductive Medicine Center) Zhu, Jie (Reproductive Medicine Center) Li, Yang (Reproductive Medicine Center)

저널정보: 대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제43권 제1호

발행연도: 2016.1

수록면: 31 - 37 (7page)

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Objective: The aim of this study was to investigate associations between the morphology score of blastocysts and blastocoele re-expansion speed after warming with clinical outcomes, which could assist in making correct and cost-effective decisions regarding the appropriate time to vitrify blastocysts and to transfer vitrified-warmed blastocysts. Methods: A total of 327 vitrified-warmed two-blastocyst transfer cycles in women 38 years old and younger were included in this retrospective study. Results: The clinical pregnancy rate (CPR) and implantation rate (IR) of transfers of two good-morphology grade 4 blastocysts vitrified on day 5 (64.1% and 46.8%, respectively) were significantly higher than the CPR and IR associated with the transfers of two good-morphology grade 3 blastocysts vitrified on day 5 (46.7% and 32.2%, respectively). No significant differences were found in the CPR and IR among the transfers of two good-morphology grade 4 blastocysts regardless of the day of cryopreservation. Logistic regression analysis showed that blastocoele reexpansion speed after warming was associated with the CPR. Conclusion: The selection of a good-morphology grade 4 blastocyst to be vitrified could be superior to the choice of a grade 3 blastocyst. Extending the culture of grade 3 blastocysts and freezing grade 4 or higher blastocysts on day 6 could lead to a greater likelihood of pregnancy. Since re-expansion was shown to be a morphological marker of superior blastocyst viability, blastocysts that quickly re-expand after warming should be prioritized for transfer.

#Blastocyst #Embryo transfer #Embryonic development #Freezing #Pregnancy outcome

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