Effects of Wearing Bio-active Material Coated Fabric against γ-irradiation-induced Cellular Damage in Sprague-Dawley Rats

Kang, Jung Ae; Kim, Hye Rim; Yoon, Sunhye; Nam, You Ree; Park, Sang Hyun; Go, Kyung-Chan; Yang, Gwang-Wung; Rho, Young-Hwan; Park, Hyo-Suk; Jang, Beom Su

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자료유형: 학술저널

저자정보: Kang, Jung Ae (Korea Atomic Energy Research Institute) Kim, Hye Rim (Korea Atomic Energy Research Institute) Yoon, Sunhye (Korea Atomic Energy Research Institute) Nam, You Ree (Korea Atomic Energy Research Institute) Park, Sang Hyun (Korea Atomic Energy Research Institute) Go, Kyung-Chan (Research and Development Center, VENTEX Co. Ltd.) Yang, Gwang-Wung (Research and Development Center, VENTEX Co. Ltd.) Rho, Young-Hwan (Research and Development Center, VENTEX Co. Ltd.) Park, Hyo-Suk (Research and Development Center, VENTEX Co. Ltd.) Jang, Beom Su (Korea Atomic Energy Research Institute)

저널정보: 대한방사선방어학회 방사선방어학회지 방사선방어학회지 제41권 제3호

발행연도: 2016.1

수록면: 206 - 210 (5page)

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Background: Ionizing radiation causes cellular damage and death through the direct damage and/or indirectly the production of ROS, which induces oxidative stress. This study was designed to evaluate the in vivo radioprotective effects of a bio-active material coated fabric (BMCF) against ${\gamma}$-irradiation-induced cellular damage in Sprague-Dawley (SD) rats. Materials and Methods: Healthy male SD rats wore bio-active material coated (concentrations in 10% and 30%) fabric for 7 days after 3 Gy of ${\gamma}$-irradiation. Radioprotective effects were evaluated by performing various biochemical assays including spleen and thymus index, WBC count, hepatic damage marker enzymes [aspartate transaminase (AST) and alanine transaminase (ALT)] in plasma, liver antioxidant enzymes, and mitochondrial activity in muscle. Results and Discussions: Exposure to ${\gamma}$-irradiation resulted in hepatocellular and immune systemic damage. Gamma-irradiation induced decreases in antioxidant enzymes. However, wearing the BMCF-30% decreased significantly AST and ALT activities in plasma. Furthermore, wearing the BMCF-30% increased SOD (superoxide dismutase) and mitochondrial activity. Conclusion: These results suggest that wearing BMCF offers effective radioprotection against ${\gamma}$-irradiation-induced cellular damage in SD rats.

#BMCF #${gamma}$-irradiation #Cellular damage

참고문헌 (14)

참고문헌 신청

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