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자료유형
학술저널
저자정보
Chung, June-Key (Department of Nuclear Medicine, Seoul National University College of Medicine) Youn, Hye-Won (Department of Nuclear Medicine, Seoul National University College of Medicine) Kang, Joo-Hyun (Molecular Imaging Research Center, KIRAMS) Lee, Ho-Young (Department of Nuclear Medicine, Seoul National University College of Medicine) Kang, Keon-Wook (Department of Nuclear Medicine, Seoul National University College of Medicine)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제44권 제1호
발행연도
2010.1
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4 - 14 (11page)

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Since the specific accumulation of iodide in thyroid was found in 1915, radioiodine has been widely applied to diagnose and treat thyroid cancer. Iodide uptake occurs across the membrane of the thyroid follicular cells and cancer cells through an active transporter process mediated by the sodium iodide symporter (NIS). The NIS coding genes were cloned and identified from rat and human in 1996. Evaluation of the NIS gene and protein expression is critical in the management of thyroid cancer, and several approaches have been tried to increase NIS levels. Identification of the NIS gene has provided a means of expanding its role in the radionuclide gene therapy of nonthyroidal cancers as well as thyroid cancer. In this article, we explain the relationship between NIS expression and the treatment of thyroid carcinoma with I-131, and we include a review of the results of our experimental and clinical trials.

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