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논문 기본 정보

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학술저널
저자정보
Chong, A-Ri (Department of Nuclear Medicine, Chonnam National University Medical School) Song, Ho-Chun (Department of Nuclear Medicine, Chonnam National University Medical School) Min, Jung-Joon (Department of Nuclear Medicine, Chonnam National University Medical School) Jeong, Shin-Young (Department of Nuclear Medicine, Kyungpook National University Hospital) Ha, Jung-Min (Department of Nuclear Medicine, Chosun University Hospital) Kim, Ja-Hae (Department of Nuclear Medicine, Chonnam National University Medical School) Yoo, Su-Ung (Department of Nuclear Medicine, Chonnam National University Medical School) Oh, Jong-Ryool (Department of Nuclear Medicine, Chonnam National University Medical School) Bom, Hee-Seung (Department of Nuclear Medicine, Chonnam National University Medical School)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제44권 제4호
발행연도
2010.1
수록면
273 - 281 (9page)

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Purpose The purpose of this study is to compare posttherapy third day and seventh day I-131 whole body scans (3DWBS and 7DWBS) in detecting lung or bone metastasis from well-differentiated thyroid cancer. Materials and Methods We enrolled 52 patients with lung or bone metastasis out of 1,152 patients who were treated with high-dose I-131 therapy from January 2008 to June 2009. All patients underwent 3DWBS and 7DWBS. I-131 avidity was classified into three grades: no uptake, suspicious for uptake, and definite uptake. We compared the presence and grades of metastatic lesions on each scan. We categorized all cases into three groups based on I-131 uptake on each scan and compared several clinical parameters including FDG uptake and thyroglobulin (Tg) level among the groups. Results Sixty metastatic cases from 52 patients (45 lung and 15 bone metastases) were included. In 35 cases, I-131-avid metastatic lesions were detected by both 3DWBS and 7DWBS (group A). In 15 cases, metastatic lesions were missed on 3DWBS but detected on 7DWBS (group B). In 10 cases, I-131 uptake was not detected on either 3DWBS or 7DWBS (group C). Ten of 45 cases (22.2%) of lung metastasis that were negative on 3DWBS were detected on 7DWBS (p=0.002). Five of 15 cases (33.3%) of bone metastasis that were negative on 3DWBS were detected on 7DWBS (p=0.0625). The serum Tg level (TSH stimulated) was significantly different among groups A, B, and C (p=0.0030). However, after exclusion of cases without a history of I-131 therapy, there was no significant difference in serum Tg level among the groups (p=0.2330). The number of cases with a prior history of metastasis was higher in group A than in group B (p=0.0069). However, there was no significant difference in prior history of metastasis between groups A and C (p=0.8107). Conclusion 7DWBS showed more lung or bone metastatic lesions than 3DWBS. After high-dose I-131 therapy, 7DWBS should be considered regardless of the results of the 3DWBS for the diagnosis of lung or bone metastasis from well-differentiated thyroid cancer.
#Thyroid cancer #Distant metastasis #I-131 #Post-therapy scan #Scan time

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참고문헌 (22)

참고문헌 신청
Cooper DS / 2009 / Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 19:1167~1214 google schola Schlumberger M / 1986 / Long-term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma / J Clin Endocrinol Metab 63:960~967 google schola Casara D / 1991 / Distant metastases in differentiated thyroid cancer: long-term results of radioiodine treatment and statistical analysis of prognostic factors in 214 patients / Tumori 77:432~436 google schola Samaan NA / 1985 / Pulmonary metastasis of differentiated thyroid carcinoma: treatment results in 101 patients / J Clin Endocrinol Metab 60:376~380 google schola Mazzaferri EL / 2001 / Clinical review 128: current approaches to primary therapy for papillary and follicular thyroid cancer / J Clin Endocrinol Metab 86:1447~1463 google schola

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