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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 388 - 393 (6page)
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초록· 키워드
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Bone metastasis is common in lung cancer patient and the diagnosis of bone metastasis is usually made by using imaging techniques, especially bone scintigraphy. However, the diagnostic yield from bone scintigraphy is limited. The aim of this study is to assess the clinical usefulness of urinary pyridinoline cross-linked N-telopeptides of Type I collagen (NTx), urinary deoxypyridinoline (DPD), and serum alkaline phosphatase (ALP) in the assessment of bone metastasis in patients with lung cancer. Urinary NTx, DPD, and serum ALP were measured in 151 lung cancer patients (33 with and 118 without bone metastasis). Lung cancer patients with bone metastasis had a higher urinary excretion of NTx and DPD, and a higher serum ALP than those without bone metastasis. NTx had a better receiver operating characteristic (ROC) curve than DPD and ALP, since the areas under the ROC curve were 0.82, 0.79, and 0.71, respectively. Although correlation coefficients among NTx, DPD and ALP were significantly positive (p<0.005), the strongest relationship was appeared between NTx and DPD (R=0.616). In conclusion, our results showed the utility of the new bone markers in detecting bone metastasis and suggested that measurement of urinary NTx was valid diagnostic method of bone metastasis from lung cancer.
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참고문헌 (15)
참고문헌 신청
/ / A specific immunoassay for monitoring human bone resorption quantitation of type I collagen cross-linked N-telopeptides in urine : 1251 ~ 8
/ / Alkaline phosphatase isoenzyme patterns in malignant disease : 2546 ~ 51
/ / Presenting conditions of 1539 population-based lung cancer patients by cell type and stage in New Hampshire and Vermont : 2107 ~ 11
/ / Urinary bone resorption markers in patients with metabolic bone disorders : 5 ~ 20
/ / Urinary pyridinoline and deoxypyridinoline in prostate carcinoma patients with bone metastasis : 701 ~ 3
/ / Alkaline phosphatase isoenzyme patterns in malignant disease : 2546 ~ 51
/ / Presenting conditions of 1539 population-based lung cancer patients by cell type and stage in New Hampshire and Vermont : 2107 ~ 11
/ / Urinary bone resorption markers in patients with metabolic bone disorders : 5 ~ 20
/ / Urinary pyridinoline and deoxypyridinoline in prostate carcinoma patients with bone metastasis : 701 ~ 3
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