지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 487 - 490 (4page)
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초록· 키워드
오류제보하기
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a relapsing-remitting disorder for which steroid administration is a key to control the progression. CLIPPERS can exhibit radiological features similar to malignant lymphoma, whose diagnosis is confounded by prior steroid administration. We report a case of CLIPPERS accompanied by abnormal elevation of ${\beta}-2$ microglobulin in the cerebrospinal fluid (CSF). A 62-year-old man started to experience numbness in all fingers of his left hand one year ago, which gradually extended to his body trunk and legs on both sides. Magnetic resonance imaging demonstrated numerous small enhancing spots scattered in his brain and spinal cord. CSF levels of ${\beta}-2$ microglobulin were elevated; although this often indicates central nervous system involvement in leukemia and lymphoma, the lesions were diagnosed as CLIPPERS based on the pathological findings from a biopsy specimen. We emphasize the importance of biopsy to differentiate between CLIPPERS and malignant lymphoma because the temporary radiological response to steroid might be the same in both diseases but the treatment strategies regarding the use of steroid are quite different.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Bagnato F. / 2004 / beta2-microglobulin serum level is not a marker of disease activity in multiple sclerosis / Eur J Neurol 11:455~460
Baraniskin A. / 2011 / Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system / Blood 117:3140~3146
Buttmann M. / 2013 / Atypical chronic lymphocytic inflammation with pontocerebellar perivascular enhancement responsive to steroids(CLIPPERS), primary angiitis of the CNS mimicking CLIPPERS or overlap syndrome? A case report / J Neurol Sci 324:183~186
Mavlight GM. / 1980 / Diagnosis of leukemia or lymphoma in the central nervous system by beta 2-microglobulin determination / N Engl J Med 303:718~722
Oksanen V. / 1986 / Cerebrospinal fluid lysozyme and beta 2-microglobulin in neurosarcoidosis / J Neurol Sci 73:79~87
Baraniskin A. / 2011 / Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system / Blood 117:3140~3146
Buttmann M. / 2013 / Atypical chronic lymphocytic inflammation with pontocerebellar perivascular enhancement responsive to steroids(CLIPPERS), primary angiitis of the CNS mimicking CLIPPERS or overlap syndrome? A case report / J Neurol Sci 324:183~186
Mavlight GM. / 1980 / Diagnosis of leukemia or lymphoma in the central nervous system by beta 2-microglobulin determination / N Engl J Med 303:718~722
Oksanen V. / 1986 / Cerebrospinal fluid lysozyme and beta 2-microglobulin in neurosarcoidosis / J Neurol Sci 73:79~87
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