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논문 기본 정보

자료유형
학술저널
저자정보
Choi, Kyung-Chul (Department of Neurosurgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine) Yoo, Do-Sung (Department of Neurosurgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine) Cho, Kyung-Sock (Department of Neurosurgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine) Huh, Pil-Woo (Department of Neurosurgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine) Kim, Dal-Soo (Department of Neurosurgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine) Park, Chun-Kun (Department of Neurosurgery, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제44권 제6호
발행연도
2008.1
수록면
375 - 381 (7page)

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Objective : The effects on neural proliferation and differentiation of neural stem cells (NSC) of basic fibroblast growth factor-2 (bFGF). insulin growth factor-I (IGF-I). brain-derived neurotrophic factor (BDNF). and nerve growth factor (NGF) were assessed. Also, following combinations of various factors were investigated : bFGF+IGF-I, bFGF+BDNF, bFGF+NGF, IGF-I+BDNF, IGF-I+NGF, and BDNF+NGF. Methods : Isolated NSC of Fisher 344 rats were cultured with individual growth factors, combinations of factors, and no growth factor (control) for 14 days. A proportion of neurons was analyzed using $\beta$-tubulin III and NeuN as neural markers. Results : Neural differentiations in the presence of individual growth factors for $\beta$-tubulin III-positive cells were : BDNF, 35.3%; IGF-I, 30.9%; bFGF, 18.1%; and NGF, 15.1%, and for NeuN-positive cells was : BDNF, 34.3%; bFGF, 32.2%; IGF-I, 26.6%; and NGF, 24.9%. However, neural differentiations in the absence of growth factor was only 2.6% for $\beta$-tubulin III and 3.1% for NeuN. For $\beta$-tubulin III-positive cells, neural differentiations were evident for the growth factor combinations as follows : bFGF+IGF-I, 73.1 %; bFGF+NGF, 65.4%; bFGF+BDNF, 58.7%; BDNF+IGF-I, 52.2%; NGF+IGF-I, 40.6%; and BDNF+NGF, 40.0%. For NeuN-positive cells : bFGF+IGF-I, 81.9%; bFGF+NGF, 63.5%; bFGF+BDNF, 62.8%; NGF+IGF-I, 62.3%; BDNF+NGF, 56.3%; and BDNF+IGF-I, 46.0%. Significant differences in neural differentiation were evident for single growth factor and combination of growth factors respectively (p<0.05). Conclusion : Combinations of growth factors have an additive effect on neural differentiation. The most prominent neural differentiation results from growth factor combinations involving bFGF and IGF-I. These findings suggest that the combination of a mitogenic action of bFGF and post-mitotic differentiation action of IGF-I synergistically affects neural proliferation and NSC differentiation.
#Neuron #Single growth factor #Combination of growth factors #Synergistic effect

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참고문헌 (38)

참고문헌 신청
Altman J / 1965 / Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats / J Comp Neurol 124:319~335 google schola Arsenijevic Y / 1998 / Insulin-like growth factor-I is a differentiation factor for postmitotic CNS stem cell-derived neuronal precursors : distinct actions from those of brain-derived neurotrophic factor / J Neurosci 18:2118~2128 google schola Arsennijevic Y / 2001 / Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2 / J Neurosci 21:7194~7202 google schola Bartlett WP / 1991 / Localization of insulin-like growth factor-1 mRNA in murine central nervous system during postnatal development / Dev Biol 147:239~250 google schola Beck KD / 1993 / The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth factor-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture / Neuroscience 52:855~866 google schola

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