지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제17권 제1호
- 발행연도
- 2012.1
- 수록면
- 10 - 15 (6page)
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초록· 키워드
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Insulin like growth factor (IGF)-1 signaling through type 1 IGF receptor (IGF1R) is essential to the normal growth and development of the central nervous system. IGF-1 stimulates proliferation of neural stem cells and neural progenitors. IGF-1 also promotes survival and differentiation of neurons and oligodendrocytes, including neuritic outgrowth,synaptogenesis, and myelin production. The phosphatidylinositol 3 kinase (PI3)-Akt pathway and mitogen-activated protein (MAP) kinase pathway are two predominant mediators of IGF1-IGF1R signaling in neural cells. β-catenin, a key molecule of the canonical Wnt signaling pathway, is also a downstream target of PI3-Akt-glycogen synthase kinase 3β(GSK3β) pathway. IGF-1 signaling through IGF1R interacts with canonical Wnt pathway at the levels of GSK3β and β-catenin rather than at the levels of Wnt ligands and Frizzled receptors to promote neural proliferation in developing central nervous system.
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참고문헌 (22)
참고문헌 신청
Abuzzahab MJ / 2003 / IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation / N Engl J Med 349 : 2211 ~ 2222
Arsenijevic Y / 2001 / Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibrobla
Beck KD / 1995 / Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal arvalbumin-containing neurons / Neuron
Brooker GJ / 2000 / Endogenous IGF-1 regulates the neuronal differentiation of adult stem cells / J Neurosci Res 59 : 332 ~ 341
D'Ercole AJ / 2002 / Mutant mouse models of insulin-like growth factor actions in the central nervous system / Neuropeptides 36 : 209 ~ 220
Arsenijevic Y / 2001 / Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibrobla
Beck KD / 1995 / Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal arvalbumin-containing neurons / Neuron
Brooker GJ / 2000 / Endogenous IGF-1 regulates the neuronal differentiation of adult stem cells / J Neurosci Res 59 : 332 ~ 341
D'Ercole AJ / 2002 / Mutant mouse models of insulin-like growth factor actions in the central nervous system / Neuropeptides 36 : 209 ~ 220
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