지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 752 - 760 (9page)
이용수
초록· 키워드
오류제보하기
Gamma-linolenic acid methyl ester (methyl GLA) was purified from the cultures of Rhizopus oryzae KSD-815, which is a filamentous fungus and has been used to make Korean traditional alcoholic beverage. In the present study, molecular mechanisms by which methyl GLA induces apoptosis in human prostate cancer cells, LNCaP, were investigated. It was found that methyl GLA mediated-apoptosis was provoked by down-regulation of mammalian target of rapamycin (mTOR) pathway, resulting from activation of AMP-activated protein kinase (AMPK) pathway and inactivation of Akt. On the other hand, a marked increase of p38 mitogen-activated protein kinase (MAPK) phosphorylation was observed within 30 min after methyl GLA treatment. Although p38 MAPK specific inhibitor, SB203580, completely blocked caspase-9 activation but not caspase-8, p38 MAPK activation was not affected by the broad caspase inhibitor, Z-VAD-FMK, which nevertheless prevented methyl GLA-provoked apoptosis. Interestingly, interference of methyl GLA-mediated p38 MAPK with SB203580 attenuated inactivation of mTOR, independent of AMPK pathway. Results indicate that methyl GLA can independently utilize two different signaling pathways for inducing the apoptosis cascade, and p38 MAPK activation is a specific regulatory role in methyl GLA-provoked apoptosis, enhancing the action mechanisms by fermentation metabolites to regulate cell death.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
누룩(Rhizopus oryzae KSD-815)으로부터 분리한 지질화합물의 세포독성 및 항염증 활성
Applied Biological Chemistry
2008 .01
-
제초제 glufosinate-ammonium의 지렁이 및 토양 미생물과 작물에 미치는 영향
농약과학회지
2006 .06
-
Sexually Matured Female Mice showed Higher γ-Linolenic Acid (GLA) in the Muscle Tissue
한국수정란이식학회지
2015 .01
-
Effect of dietary gamma-linolenic acid on milk production in cow
Korean Journal of Agricultural Science
2016 .06
-
식용식물자원으로부터 활성물질의 탐색-XX. 순무(Brassica campestris ssp rapa)뿌리로부터 지질화합물의 분리
Applied Biological Chemistry
2007 .01
-
Extracts from Rhizopus oryzae KSD-815 of Korean Traditional Nuruk Confer the Potential to Inhibit Hypertension, Platelet Aggregation, and Cancer Metastasis in vitro
Food Science and Biotechnology
2009 .12
-
Supplementation of Either Conjugated Linoleic Acid or γ-linolenic Acid with or without Carnitine to Pig Diet Affect Flavor of Pork and Neutrophil Phagocytosis
한국축산학회지
2011 .01
-
HepG2 간암세포에서 미토콘드리아 경로를 통한 개똥쑥 추출물의 Apoptosis 유도 효과
한국식품영양과학회지
2016 .12
-
Pyrogallol Induces G0/G1 Cell Cycle Arrest and Apoptosis through Mitochondrial Pathway in PC-3 Human Prostate Cancer Cells
한국식품영양과학회 학술대회발표집
2018 .10
-
Ursolic acid induces G0/G1 cell cycle arrest by regulating AKT/p53/p21 and MAPK signaling pathways in breast cancer stem-like cells
한국식품영양과학회 학술대회발표집
2019 .10
-
Regulation of Caspase Activity During Apoptosis Induced by Baicalein in HL60 Human Leukemia Cell Line
Food Science and Biotechnology
2008 .12
-
감마선과 Methyl Bromide 처리가 사과의 생리화학적 품질에 미치는 영향
Food Science and Preservation
2003 .09
-
A1E Induces Apoptosis via Targeting HPV E6/E7 Oncogenes and Intrinsic Pathways in Cervical Cancer Cells
Journal of applied biological chemistry
2014 .01
-
Effects of Korean Red Ginseng Extract on Endothelial Proliferation and Angiogenesis through Activating the MAPK and PI3K/AKT/mTOR Signaling Pathway
한국식품영양과학회 학술대회발표집
2017 .10
-
Analysis of MAPK Signaling Pathway Genes in the Intestinal Mucosal Layer of Necrotic Eenteritis-Afflicted Two Inbred Chicken Lines
한국가금학회지
2017 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0