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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 1,305 - 1,309 (5page)
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Baicalein, one of the major flavonoid in Scutellaria baicalensis, has been known for its effects on proliferation and apoptosis of many tumor cell lines. Most biological effects of baicalein are thought to be from its antioxidant and prooxidant activities. In this report, baicalein was found to induce apoptosis in HL60 human promyelocytic leukemia cell line. Baicalein treatment induced DNA fragmentation and typical morphological features of apoptosis. To elucidate the mechanism of baicalein-induced apoptosis, the activities of the members of caspase family were measured. Interestingly caspase 2, 3, and 6 were significantly activated whereas caspase 1, 8, and 9 were not activated, suggesting selective involvement of specific caspases. Further, treatment with caspase inhibitors also supports the involvement of caspase 2 in apoptosis process. Although it has been reported that baicalein can induce apoptosis through many caspase pathways, the present study indicates that caspase 2 not caspase 9 pathway may be the important step in apoptosis on HL60 cell line.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgment
References
참고문헌 (24)
참고문헌 신청
Vermeulen K / 2005 / Apoptosis: Mechanisms and relevance in cancer / Ann. Hematol 84:627~639
Tang W / 1992 / Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine / Springer Verlag :919
So FV / 1997 / Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen / Cancer Lett 112:127~133
Yano H / 1994 / The herbal medicine Sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase / Cancer Res 54:448~454
Motoo Y / 1994 / Antitumor effects of saikosaponins, baicalin, and baicalein on human hepatoma cell lines / Cancer Lett 86:91~95
Tang W / 1992 / Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine / Springer Verlag :919
So FV / 1997 / Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen / Cancer Lett 112:127~133
Yano H / 1994 / The herbal medicine Sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase / Cancer Res 54:448~454
Motoo Y / 1994 / Antitumor effects of saikosaponins, baicalin, and baicalein on human hepatoma cell lines / Cancer Lett 86:91~95
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UCI(KEPA) : I410-ECN-0101-2013-573-000858529