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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제62권 제1호
- 발행연도
- 2019.1
- 수록면
- 57 - 66 (10page)
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The ethyl acetate fraction of Bat Faeces (Ye Ming Sha: natural products used in Chinese Medicine) after fermentation (EFBF-AF) showed enhanced anti-oxidative effects in 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt assays. Fermentation of the Bat Faeces by using the crude enzyme extract from Aspergillus kawachii, significantly increased the anti-inflammatory effects. Fermented Bat Faeces markedly inhibited nitric oxide production, inducible nitric oxide synthase, and cyclooxygenase-2 expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The EFBF-AF reduced the nuclear translocation of nuclear factor kappa B ($NF-{\kappa}B$) via $IKK{\alpha}$ and $I{\kappa}B{\alpha}$ phosphorylation, and decreased the phosphorylated the extracellular signal-regulated kinases (ERK) and p38 expression in LPS-treated RAW 264.7 macrophages. In addition, the EFBF-AF suppressed the expression of pro-inflammatory genes, such as interleukin-$1{\beta}$, interleukin-6, and tumor necrosis $factor-{\alpha}$. These results suggest that fermented Bat Faeces may suppress pro-inflammatory responses in LPS-stimulated RAW 264.7 macrophages cells via ERK, p38 mitogen-activated protein kinase and $NF-{\kappa}B$ signaling pathways.
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참고문헌 (35)
참고문헌 신청
Li SX / 2003 / Speciation analysis of iron in traditional Chinese medicine by flame atomic absorption spectrometry / J Pharmaceut Biomed 32:51~57
Guo Y / 1997 / Sustainability of wildlife use in raditional Chinese medicine / Conserving China’s Biodiversity :190~220
Riccucci M / 2012 / Bats as materia medica : an ethnomedical review and implications for conservation / Vespertillio 16:249~270
Choe E / 2005 / Chemistry and reactions of reactive oxygen species in foods / J Food Sci 70:R142~R159
Suja KP / 2005 / Antioxidant activity of sesame cake extract / Food Chem 91:213~219
Guo Y / 1997 / Sustainability of wildlife use in raditional Chinese medicine / Conserving China’s Biodiversity :190~220
Riccucci M / 2012 / Bats as materia medica : an ethnomedical review and implications for conservation / Vespertillio 16:249~270
Choe E / 2005 / Chemistry and reactions of reactive oxygen species in foods / J Food Sci 70:R142~R159
Suja KP / 2005 / Antioxidant activity of sesame cake extract / Food Chem 91:213~219
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