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논문 기본 정보

자료유형
학술저널
저자정보
Jeong, Jin-Woo (Anti-Aging Research Center and Department of Biochemistry, Dongeui University College of Korean Medicine) Cha, Hee-Jae (Departments of Parasitology and Genetics, Kosin University College of Medicine) Han, Min Ho (Natural products Research Team, Marine Biodiversity Institute of Korea) Hwang, Su Jung (Department of Pharmacy, College of Pharmacy, Inje University) Lee, Dae-Sung (Natural products Research Team, Marine Biodiversity Institute of Korea) Yoo, Jong Su (Natural products Research Team, Marine Biodiversity Institute of Korea) Choi, Il-Whan (Department of Microbiology, College of Medicine, Inje University) Kim, Suhkmann (Department of Chemistry, College of Natural Sciences, Pusan National University) Kim, Heui-Soo (Department of Biological Sciences, College of Natural Sciences, Pusan National University) Kim, Gi-Young (Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University) Hong, Su Hyun (Anti-Aging Research Center and Department of Biochemistry, Dongeui University College of Korean Medicine) Park, Cheol (Department of Molecular Biology, College of Natural Sciences & Human Ecology, Dongeui Univ) Lee, Hyo-Jong Choi, Yung Hyun
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제26권 제2호
발행연도
2018.1
수록면
146 - 156 (11page)

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Spermidine is a naturally occurring polyamine compound that has recently emerged with anti-aging properties and suppresses inflammation and oxidation. However, its mechanisms of action on anti-inflammatory and antioxidant effects have not been fully elucidated. In this study, the potential of spermidine for reducing pro-inflammatory and oxidative effects in lipopolysaccharide (LPS)-stimulated macrophages and zebrafish was explored. Our data indicate that spermidine significantly inhibited the production of pro-inflammatory mediators such as nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$), and cytokines including tumor necrosis $factor-{\alpha}$ and $interleukin-1{\beta}$ in RAW 264.7 macrophages without any significant cytotoxicity. The protective effects of spermidine accompanied by a marked suppression in their regulatory gene expression at the transcription levels. Spermidine also attenuated the nuclear translocation of $NF-{\kappa}B$ p65 subunit and reduced LPS-induced intracellular accumulation of reactive oxygen species (ROS) in RAW 264.7 macrophages. Moreover, spermidine prevented the LPS-induced NO production and ROS accumulation in zebrafish larvae and was found to be associated with a diminished recruitment of neutrophils and macrophages. Although more work is needed to fully understand the critical role of spermidine on the inhibition of inflammation-associated migration of immune cells, our findings clearly demonstrate that spermidine may be a potential therapeutic intervention for the treatment of inflammatory and oxidative disorders.
#Spermidine #Macrophages #Zebrafish #Anti-Inflammation #Anti-Oxidant

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참고문헌 (47)

참고문헌 신청
Aderem, A. / 2000 / Toll-like receptors in the induction of the innate immune response / Nature 406:782~787 Crossref Amin, A. R. / 1999 / Nitric oxide synthase and cyclooxygenases: distribution, regulation, and intervention in arthritis / Curr. Opin. Rheumatol. 11:202~209 Crossref Brune, B. / 2013 / Redox control of inflammation in macrophages / Antioxid. Redox Signal. 19:595~637 Crossref Cheong, S. H. / 2016 / Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one in zebrafish embryos in vivo model / Fish Shellfish Immunol. 50:16~20 Crossref Choi, Y. H. / 2012 / Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells / J. Biomed. Sci. 19:31 Crossref

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