지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 320 - 327 (8page)
이용수
초록· 키워드
오류제보하기
Columbianadin (CBN), a natural coumarin from Angelica decursiva (Umbelliferae), is known to have various biological activities including anti-inflammatory and anti-cancer effects. In this study, the anti-proliferative mechanism of actions mediated by CBN was investigated in HCT-116 human colon cancer cells. CBN effectively suppressed the growth of colon cancer cells. Low concentration (up to $25{\mu}M$) of CBN induced apoptosis, and high concentration ($50{\mu}M$) of CBN induced necroptosis. The induction of apoptosis by CBN was correlated with the modulation of caspase-9, caspase-3, Bax, Bcl-2, Bim and Bid, and the induction of necroptosis was related with RIP-3, and caspase-8. In addition, CBN induced the accumulation of ROS and imbalance in the intracellular antioxidant enzymes such as SOD-1, SOD-2, catalase and GPx-1. These findings demonstrate that CBN has the potential to be a candidate in the development of anti-cancer agent derived from natural products.
목차
등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Ames, B. N / 1983 / Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases / Science 221:1256~1264
Birben, E / 2012 / Oxidative stress and antioxidant defense / World Allergy Organ. J 5:9~19
Cerutti, P / 1988 / Physiological and pathologic effects of oxidants in mouse epidermal cells / Ann. N. Y. Acad. Sci 55:75~81
Cerutti, P. A / 1985 / Prooxidant states and tumor promotion / Science 227:375~381
Chen, Y. F / 1995 / Anti-inflammatory and analgesic activities from roots of Angelica pubescens / Planta Med 61:2~8
Birben, E / 2012 / Oxidative stress and antioxidant defense / World Allergy Organ. J 5:9~19
Cerutti, P / 1988 / Physiological and pathologic effects of oxidants in mouse epidermal cells / Ann. N. Y. Acad. Sci 55:75~81
Cerutti, P. A / 1985 / Prooxidant states and tumor promotion / Science 227:375~381
Chen, Y. F / 1995 / Anti-inflammatory and analgesic activities from roots of Angelica pubescens / Planta Med 61:2~8
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Shikonin Induced Necroptosis via Reactive Oxygen Species in the T-47D Breast Cancer Cell Line
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Cigarette smoke components induced apoptosis in SW620 human colon cancer cells via ROS-induced ER-stress pathway
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Inhibitory Effects of Schisandra chinensis Seed Extracts on Breast Cancer
대한의생명과학회지
2025 .03
-
Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Kaempferol Synergistically Enhances Cisplatin-induced Apoptosis and Cell Cycle Arrest in Colon Cancer Cells
대한암예방학회지
2024 .09
-
Quercetin Down-regulates IL-6/STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Non-small-cell Lung-cancer Cell Line, A549
Journal of Pharmacopuncture
2015 .01
-
Cobalt Chloride Induces Necroptosis in Human Colon Cancer HT-29 Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
간호대학생의 핵심기본간호술 수행자신감 영향 요인
기본간호학회지
2015 .08
-
Oxidative Stress-Induced Apoptosis in Chronic Myelogenous Leukemia K562 Cells by an Active Compound from the Dithio-Carbamate Family
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Harmal Extract Induces Apoptosis of HCT116 Human Colon Cancer Cells, Mediated by Inhibition of Nuclear Factor-κB and Activator Protein-1 Signaling Pathways and Induction of Cytoprotective Genes
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Bacillus spp. or Bacillus spp.-Derived Membrane Vesicles Induce the Intrinsic Pathways of Apoptosis of Human Colon Cancer Cell Lines
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .06
-
Betaine Effects on Morphology, Proliferation, and p53-induced Apoptosis of HeLa Cervical Carcinoma Cells in Vitro
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells
Gut and Liver
2016 .01
-
Ginsenoside-Rh2 Inhibits Proliferation and Induces Apoptosis of Human Gastric Cancer SGC-7901 Side Population Cells
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Vinpocetine inhibits proliferation and induces apoptosis in human colon cancer cells
International Journal of Oral Biology
2021 .01
-
MS-5, a Naphthalene Derivative, Induces the Apoptosis of an Ovarian Cancer Cell CAOV-3 by Interfering with the Reactive Oxygen Species Generation
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Evaluation of Effects of Metformin in Primary Ovarian Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Effects of Amifostine on Apoptosis, Cell Cycle and Cytoprotection of Human Colon Cancer Cell Lines
대한의생명과학회지
2023 .12
-
Induction of Apoptosis by Eugenol and Capsaicin in Human Gastric Cancer AGS Cells - Elucidating the Role of p53
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Pseudolaric acid B induces growth inhibition and caspase-dependent apoptosis on head and neck cancer cell lines through death receptor 5
한국실험동물학회 학술발표대회 논문집
2020 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0