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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 367 - 373 (7page)
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초록· 키워드
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Cordyceps species including Cordyceps bassiana are a notable anti-cancer dietary supplement. Previously, we identified several compounds with anti-cancer activity from the butanol fraction (Cb-BF) of Cordyceps bassiana. To expand the structural value of Cb-BF-derived anti-cancer drugs, we employed various chemical moieties to produce a novel Cb-BF-derived chemical derivative, KTH-13-amine-monophenyl [4-isopropyl-2-(1-phenylethyl) aniline (KTH-13-AMP)], which we tested for anti-cancer activity. KTH-13-AMP suppressed the proliferation of MDA-MB-231, HeLa, and C6 glioma cells. KTH-13-AMP also dose-dependently induced morphological changes in C6 glioma cells and time-dependently increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, the levels of the active full-length forms of caspase-3 and caspase-9 were increased. In contrast, the levels of total forms of caspases-3, caspase-8, caspase-9, and Bcl-2 were decreased in KTH-13-AMP treated-cells. We also confirmed that the phosphorylation of STAT3, Src, and PI3K/p85, which is linked to cell survival, was diminished by treatment with KTH-13-AMP. Therefore, these results strongly suggest that this compound can be used to guide the development of an anti-cancer drug or serve as a lead compound in forming another strong anti-proliferative agent.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Byeon, S. E. / 2011 / Inhibition of cytokine expression by a butanol extract from Cordyceps bassiana / Pharmazie 66:58~62
Chang, Y. / 2011 / In vitro toxicity evaluation of graphene oxide on A549 cells / Toxicol. Lett 200:201~210
Foerster, F. / 2014 / Targeting the actin cytoskeleton:selective antitumor action via trapping PKCvarepsilon / Cell Death Dis 5:e1398
Holliday, J. C. / 2008 / Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) Link (Ascomycetes). A review / Int. J. Med. Mushrooms 10:219~234
Jayakumar, T. / 2014 / Anti-cancer effects of CME-1, a novel polysaccharide, purifi ed from the mycelia of Cordyceps sinensis against B16-F10 melanoma cells / J. Cancer Res. Ther 10:43~49
Chang, Y. / 2011 / In vitro toxicity evaluation of graphene oxide on A549 cells / Toxicol. Lett 200:201~210
Foerster, F. / 2014 / Targeting the actin cytoskeleton:selective antitumor action via trapping PKCvarepsilon / Cell Death Dis 5:e1398
Holliday, J. C. / 2008 / Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) Link (Ascomycetes). A review / Int. J. Med. Mushrooms 10:219~234
Jayakumar, T. / 2014 / Anti-cancer effects of CME-1, a novel polysaccharide, purifi ed from the mycelia of Cordyceps sinensis against B16-F10 melanoma cells / J. Cancer Res. Ther 10:43~49
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