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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 160 - 167 (8page)
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Depression is a major mood disorder. Abnormal expression of glial glutamate transporter-1 (GLT-1) is associated with depression. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine for thousands of years. This paper was designed to investigate the effects of STB on depressive mice induced by forced swimming test (FST). Additionally, we also assessed the impairment of FST on cognitive function in mice with different ages. FST and open field test (OFT) were used for assessing depressive symptoms, and Y-maze was used for evaluating cognition processes. Our study showed that STB acting as an antidepressant, which increased GLT-1 levels by promoting PI3K/AKT/mTOR pathway. Although the damage is reversible, short-term learning and memory impairment caused by FST test is more serious in the aged mice, and STB also exerts cognition improvement ability in the meanwhile. Our findings suggested that STB might be a promising therapeutic agent of depression by regulating the GLT-1 restoration as well as activating PI3K/AKT/mTOR pathway.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Aydin EP / 2018 / Thioredoxin is not a marker for treatment-resistance depression but associated with cognitive function : an rTMS study / Prog. Neuropsychopharmacol. BiolPsychiatry 80:322~328
Borsoi M / 2015 / Immobility behavior during the forced swim test correlates with BNDF levels in the frontal cortex, but not with cognitive impairments / Physiol. Behav 140:79~88
Chen D / 2017 / A review of DNA methylation in depression / J. Clin. Neurosci 43:39~46
Cho S / 2018 / An herbal formula consisting of Schisandra chinensis (Turcz.) Baill, Lycium chinense Mill and Eucommia ulmoides Oliv alleviates disuse muscle atrophy in rats / J. Ethnopharmacol 213:328~339
Cognato Gde P / 2012 / Y-Maze memory task in zebrafish(Danio rerio) : the role of glutamatergic and cholinergic systems on the acquisition and consolidation periods / Neurobiol. Learn. Mem 98:321~328
Borsoi M / 2015 / Immobility behavior during the forced swim test correlates with BNDF levels in the frontal cortex, but not with cognitive impairments / Physiol. Behav 140:79~88
Chen D / 2017 / A review of DNA methylation in depression / J. Clin. Neurosci 43:39~46
Cho S / 2018 / An herbal formula consisting of Schisandra chinensis (Turcz.) Baill, Lycium chinense Mill and Eucommia ulmoides Oliv alleviates disuse muscle atrophy in rats / J. Ethnopharmacol 213:328~339
Cognato Gde P / 2012 / Y-Maze memory task in zebrafish(Danio rerio) : the role of glutamatergic and cholinergic systems on the acquisition and consolidation periods / Neurobiol. Learn. Mem 98:321~328
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